摘要
目的:探讨甘丙肽(galanin,GAL)及5-羟色胺(5-hydroxytryptamine,5-HT)在不同亚型的胃食管反流病(gastroesophageal reflux disease,GERD)患者血浆中表达水平的差异及其与焦虑、抑郁的关系.方法:采用焦虑自评量表(Self-rating Anxiety Scale,SAS)和抑郁自评量表(Self-rating Depression Scale,SDS)对GERD患者和健康对照组进行测试,评定心理状况;采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)分析GERD患者和健康对照组血浆中5-HT、GAL的含量.结果:无合并焦虑、抑郁的GERD患者与健康对照组比较,5-HT升高,GAL下降(t=1.97,P<0.05);非糜烂性反流病(non-erosive reflux disease,NERD)患者与反流性食管炎(reflux esophagitis,RE)患者比较,焦虑、抑郁问题更严重(F分别为55.92、36.51,均P<0.05),且与健康对照组相比,5-HT下降,GAL升高(F分别为54.53、8.00,均P<0.05);5-HT与SAS、SDS评分呈负相关(r分别为-0.789、-0.787、均P<0.05),GAL与SAS、SDS评分呈正相关(r分别为0.688、0.705,均P<0.05),5-HT与GAL呈负相关(r=-0.744,P<0.05).结论:无合并焦虑、抑郁的GERD患者,5-HT升高,GAL下降;NERD患者比RE患者焦虑、抑郁问题更严重,5-HT下降,GAL升高;焦虑、抑郁问题越严重,5-HT越低,GAL越高.
AIM： To investigate the difference in plasma galanin （GAL） and 5-hydroxytryptamine （5-HT） in patients with different subtypes of gastroesophageal reflux disease （GERD） and their relationship with patients＇ anxiety and depression.METHODS： The Self-rating Anxiety Scale （SAS） and Self-rating Depression Scale （SDS） were used to assess anxiety and depression in GERD patients and healthy controls. Enzyme linked immunosorbent assay （ELISA） was used to analyze the contents of 5-HT and GAL in plasma of GERD patients and healthy controls.RESULTS： Compared with the healthy control group, GERD patients without anxiety or depression had increased 5-HT and decreased GAL （t = 1.97, P 〈 0.05）. Compared with reflux esophagitis （RE） patients, non-erosive reflux disease （NERD） patients had more serious anxiety and depression （F = 55.92, 36.51, P 〈 0.05）. Compared with the control group, 5-HT decreased and GAL increased in NERD patients （F =54.53, 8.00, P 〈 0.05）. 5-HT had a negative correlation with SAS and SDS scores （r =-0.789, -0.787, P 〈 0.05）, but GAL had a positive correlation with SAS and SDS scores （r = 0.688, 0.705, P 〈 0.05）. 5-HT was negativelycorrelated with GAL （r = -0.744, P 〈 0.05）.CONCLUSION： In GERD patients without anxiety or depression, 5-HT increases and GAL decreases. NERD patients have more serious anxiety and depression problems than RE patients, and 5-HT decreases and GAL increases. The more serious anxiety and depression problems, the lower 5-HT and the higher GAL.
出处
《世界华人消化杂志》
CAS
2016年第8期1247-1251,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81173392~~
关键词
胃食管反流病
甘丙肽
5-羟色胺
精神心理因素
Gastroesophageal reflux disease
Galanin
5-hydroxytryptamine
Psychological factors
