摘要
上皮-间质转化(epithelial-to-mesenchymal transition,EMT)是一个上皮细胞转分化成间质细胞的复杂生理病理过程,参与胚胎形成、组织器官纤维化、肿瘤发生、转移等.近年来研究显示胆管细胞发生上皮-间质转化在多种胆管病包括肝胆管结石病中发挥着重要作用,并涉及b-转化生长因子/Smads信号通路的调节.文章着重介绍上皮-间质转化的概念、类型,总结胆管上皮细胞(bile duct epithelia cells,BDECs)发生EMT的研究现状及在肝胆管结石病中的作用及可能机制.
Epithelial-to-mesenchymal transition （EMT） is a complex physiological and pathological process in which epithelial cells acquire mesenchymal characteristics. EMT occurs during embryogenesis and organ development, wound healing and organ regeneration, tumor migration and invasion. In recent years, cholangiocytes have been shown to undergo EMT in different cholangiopathies including hepatolithiasis. Transforming growth factor-β/Smads signaling is considered the master regulator. The purpose of this article is to introduce the concept and type of EMT, summarize recent advances that support or refute the concept that cholangiocytes are capable of phenotype transition of hepaticlithiasis and discuss the probable mechanism.
出处
《世界华人消化杂志》
CAS
2016年第8期1153-1158,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81260085
贵州省优秀科技人才省长专项基金资助项目
No.黔省专合字[2011]26号~~
关键词
上皮-间质转化
肝胆管结石病
胆管细胞
Epithelial-to-mesenchymal transition
Hepatolithiasis
Cholangiocytes
