摘要
目的 ：分析不同血压及代谢水平患者的血浆儿茶酚抑素（CST）水平的变化特征。方法 ：选择2011-05至2012-04在我院健康查体无高血压史的血压正常者60例（血压正常组）,原发性高血压患者131例,将高血压患者按照是否符合代谢综合征诊断分为单纯高血压组90例和代谢综合征组41例。分别测定CST、去甲肾上腺素（NE）水平,计算CST/NE值。结果：与血压正常组比较,单纯高血压组、代谢综合征组患者血浆CST水平、CST/NE值明显降低[CST分别为（ng/ml）：1.41±0.39、1.23±0.41、1.04±0.36,CST/NE值分别为（ng/ml）：3.86±1.22、3.24±1.25、2.68±1.12],差异均有统计学意义（P〈0.05~0.01）。所有入选人群随血压水平升高,血浆CST水平有逐渐下降趋势,代谢综合征组CST水平、CST/NE值较单纯高血压组下降明显（P〈0.05）,差异有统计学意义。结论 ：原发性高血压患者血浆CST水平、CST/NE值明显降低,代谢综合征患者CST水平较单纯高血压患者下降,提示CST可能参与了原发性高血压和代谢综合征的发生过程。
Objective： To analyze plasma levels of catestatin（CST） in patients with different blood pressure（BP） and metabolic status. Methods： Our research included in 3 groups： Control group, n=60 subjects with normal BP from physical examination in our hospital; 131 patients with essential hypertension（EH） were divided into 2 groups： Isolated EH group, n=90 and MS（metabolic syndrome） group, n=41. Plasma levels of CST, norepinephrine（NE） were examined, the ratio of CST/NE was calculated, and those indexes were compared among different groups.Results： Compared with Control group, plasma levels of CST and the ratios of CST/NE were decreased in Isolated EH and MS groups, P〈0.05-0.01. As BP increasing, plasma levels of CST were gradually decreased; compared with Isolated EH group, plasma level of CST and CST/NE were reduced in MS group, P〈0.05.Conclusion： Plasma levels of CST and the ratio of CST/NE were obviously decreased in EH patients, CST was even lower in MS patients which implied that CST might be involved in the development of EH and MS.
出处
《中国循环杂志》
CSCD
北大核心
2016年第3期259-262,共4页
Chinese Circulation Journal
