摘要
目的观察氨磺必利治疗酒精所致精神障碍的临床疗效和不良反应以及对生活质量的改善作用,旨在为临床提供参考和借鉴。方法选取2012年1月至2015年1月精神科收治的120例酒精所致精神障碍患者,随机分为两组,每组60例。对照组在常规治疗基础上给予奋乃静,治疗组在常规治疗基础上给予氨磺必利,对比两组患者治疗前后阳性和阴性综合征(PANSS)量表各因子评分和总评分、临床疗效、不良反应及不良反应症状量表(TESS)评分、世界卫生组织生存质量量表简表中文版(WHOQOL-BREF)评分。结果两组治疗后PANSS量表各因子评分和总评分较治疗前均呈逐渐降低趋势,治疗组治疗后不同时点阴性症状、精神病理评分和总评分均明显低于对照组(P均<0.05);治疗组治疗4、8、12周总有效率均明显高于对照组(P<0.05,P<0.01);治疗组不良反应发生率16.67%明显低于对照组的41.67%(χ2=9.076,P=0.003),且程度轻微,治疗1、2、4、8、12周TESS评分均明显低于对照组(P均<0.01);两组患者治疗后WHOQOL-BREF量表各因子评分均明显高于治疗前(P均<0.05),且治疗组高于对照组(P均<0.05)。结论氨磺必利治疗酒精所致精神障碍疗效确切,不良反应少且轻微,明显改善患者生活质量,可作为临床安全有效的治疗方案。
Objective To observe the clinical efficacy and adverse reactions of amisulpride（ ASP） in the treatment of mental disorders caused by alcohol and its influence on the quality of life to provide a reference for the future clinical treatment. Methods A total of 120 patients with alcohol induced mental disorders treated in the psychiatric department of Rongkang hospital from January 2012 to January 2015 were selected and randomly divided into treatment group and control group（ n = 60 each）. Based on the conventional treatment,the patients of control group were given perphenazine,and the patients of treatment group were given ASP. Each factor score and total score of positive and negative syndrome scale（ PANSS）,clinical efficacy,adverse reactions,treatment emergent symptoms scale（ TESS） score,the score of World Health Organization Quality of life scale list（ WHOQOL-BREF） for Chinese version before and after treatment were compared between two groups. Results Compared with pre-treatment,each factor score and total score of PANSS in two groups gradually decreased after treatment,and the negative symptom score,psychopathological score and total score of PANSS in treatment group were significantly lower than those in control group（ all P 〈0. 05）. At 4-,8- and 12-week after treatment,the total effective rates in treatment group were significantly higher than those in control group（ all P 〈0. 05）. The incidence of adverse reactions in treatment group was significantly lower than that in control group（ 16. 67% vs 41. 67%,P =0. 003）,and its degree was light. TESS scores at 4-,8- and 12-week after treatment in treatment group were obviously lower than those in control group（ all P 〈0. 05）. The scores of each factor of WHOQOL-BREF after treatment in two groups were significantly higher than those before treatment（ all P 〈0. 05） and were obviously higher in treatment group than those in control group（ all P 〈0. 05）. Conclusion For the treatment of alcohol induced mental disor
出处
《中国临床研究》
CAS
2016年第3期308-311,共4页
Chinese Journal of Clinical Research
基金
河南省教育厅科学技术研究重点项目(13B320222)
关键词
氨磺必利
奋乃静
酒精所致精神障碍
不良反应
生活质量
Amisulpride
Perphenazine
Alcohol induced mental disorder
Adverse reaction
Quality of life
