摘要
目的探讨血清降钙素原、C反应蛋白、乳酸、D-二聚体水平在儿童脓毒症联合检测的意义。方法选取64例我院治疗的脓毒症,根据患儿病情情况,将脓毒症组分为一般脓毒症和重度脓毒症组,另选择32例健康儿童为正常对照组。于入院后1h内测定血清降钙素原、C反应蛋白、乳酸、D-二聚体水平。结果脓毒症患儿组血清降钙素原、C反应蛋白、乳酸、D-二聚体水平较正常儿童组明显升高,差异有统计学意义(P<0.01);重度脓毒组血清降钙素原、乳酸水平在诊断为脓毒症后的6 h、24 h、48 h比一般脓毒症组升高,差异有统计学意义(P<0.01),C反应蛋白水平在两组中比较差异无统计学意义(P>0.05);脓毒症组并发DIC者四项指标同时升高,且死亡组血清降钙素原、乳酸、D-二聚体水平比存活组更高,差异有统计学意义(P均<0.01)。结论在脓毒症患儿中联合检测血清降钙素原、C反应蛋白、乳酸、D-二聚体水平可能可以提高诊断早期脓毒症及判断病情严重程度及预后的水平。
Objective To explore the significance of combined detection of serum procalcitonin,Creactive protein,lactic acid and D-dimer levels in children with sepsis. Methods 64 cases with sepsis according to their situation were divided into general sepsis and severe sepsis group,and 32 cases healthy children were selected as control group. Serum procalcitonin,C-reactive protein,lactic acid and D-dimer levels were detected within 1h after they were hospitalized. Results Serum procalcitonin,C-reactive protein,lactic acid and D-dimer levels in sepsis group were significantly higher（ P〈0. 01） than control group; Serum procalcitonin and lactic acid levels in sepsis group after the diagnosis of 6h,24 h,48h were significantly higher than general sepsis group（ P〈0. 01）,the differences of C-reactive protein levels were not significant in the two groups（ P〉0. 05）; All the four parameters in sepsis group complicated with DIC increased at the same time,and in death group,serum procalcitonin,lactic acid and D-dimer levels were significantly higher than the survival group（ P〈0. 01）.Conclusions Combining detection of serum calcitonin original,C-reactive protein,lactic acid and D-dimer levels are helpful for the early diagnosis of sepsis in children,and can also be valuable in the evaluation of severity and prognosis.
出处
《齐齐哈尔医学院学报》
2016年第6期708-710,共3页
Journal of Qiqihar Medical University
