摘要
目的探讨慢性肾脏病（CKD）3~5期患者血清骨代谢相关指标水平的变化情况,为继发性骨代谢疾病的早期诊断与预防提供依据。方法回顾性分析本院收治的确诊为CKD 3~5期的261例患者血清中甲状旁腺激素（iPTH）、钙（Ca）、磷（P）、骨钙素（BGP）、降钙素（CT）、骨特异性碱性磷酸酶（OST）、25-羟基维生素D[25（OH）D]等指标水平的变化,并与反映肾脏功能的血清尿素（Urea）、尿酸（UA）、血肌酐（SCr）等指标进行相关性分析。结果在CKD 3~5期,血清iPTH和P水平进行性升高,差异有统计学意义（P〈0.05）;BGP和CT在CKD5期明显升高,差异有统计学意义（P〈0.01）。Spearman相关分析显示,iPTH、P与Urea、UA、SCr均呈正相关（P〈0.05）。结论 CKD 3~5期iPTH、P、BGP等指标有差异,并与Urea、UA和SCr等指标呈正相关,可辅助诊断骨代谢疾病。
Objective To investigate the changes of the serum bone metabolism indexes levels in the patients with stages 3-5chronic kidney disease（CKD）to provide the evidence for the diagnosis and prevention of secondary bone metabolic diseases.Methods Totally 261 patients with stages 3-5CKD in our hospital were performed the retrospective analysis on the levels of serum iPTH,Ca,P,BGP,CT,OST and 25（OH）D and the correlation analysis with the indexes of Urea,UA and SCr.Results The levels of iPTH and P were increased continuously in the stages3-5CKD,the differences were statistically significant（P〈0.05）.The serum BGP and CT were significantly higher in the patients with stage 5CKD with statistical difference（P〈0.01）.The Spearman′s correlation analysis showed that iPTH and P were positively correlated with Urea,UA and SCr（P〈0.05）.Conclusion The levels of iPTH,P and BGP in the patients with stages 3-5CKD are significantly different,and show the positive correlation with Urea,UA and SCr,which is helpful for diagnosing bone metabolic diseases.
出处
《检验医学与临床》
CAS
2016年第6期749-751,共3页
Laboratory Medicine and Clinic
关键词
慢性肾脏病
骨代谢指标
肾性骨病
甲状旁腺激素
chronic kidney disease
bone metabolism index
renal osteopathy
parathyroid hormone
