摘要
目的探讨氨氯地平联合缬沙坦治疗原发性高血压的疗效及对颈动脉硬化病变的逆转作用,为临床治疗提供参考依据。方法选择浙江省金华市中医医院心血管内科2012年8月~2014年8月收治的100例原发性高血压患者作为研究对象,根据随机数字表法分为观察组和对照组各50例。对照组给予氨氯地平治疗,观察组在对照组治疗的基础上加用缬沙坦治疗。治疗6个月后比较2组患者的血压控制效果及颈动脉内膜中层厚度（intima-media thickness,IMT）、斑块长径、斑块厚度变化情况。结果治疗6个月后,观察组24 h收缩压（SBP）、24 h舒张压（DBP）及24 h平均动脉压（MAP）分别为（125.6±6.5）、（73.7±5.5）、（68.5±5.6）mm Hg,均显著低于对照组[（130.4±8.6）、（78.4±6.2）、（73.9±6.3）mm Hg,P〈0.05];观察组斑块厚度、斑块长径及IMT分别为（1.51±0.64）、（5.85±2.24）、（0.92±0.06）mm,均显著低于对照组[（1.76±0.52）、（6.83±2.06）、（0.95±0.07）mm,P〈0.05];观察组总甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）显著低于对照组,高密度脂蛋白胆固醇（HDL-C）显著高于对照组（P〈0.05）。结论氨氯地平联合缬沙坦可显著提高原发性高血压患者的血压控制效果,可有效逆转患者颈动脉硬化病变,且无严重不良反应发生。
Objective To investigate the reverse treatment of amlodipine combined with valsartan in patients with primary hypertension and arteriosclerosis disease and provide reference for clinical treatment. Methods 100 cases of primary hypertension treated in the hospital from August 2012 to August 2014 were divided into observation group and control group according to the random number table method,50 cases in each group. The control group were treated with amlodipine,the observation group were treated with valsartan on the basis of control group. After 6 months of treatment,the blood pressure control effect,carotid intima-media thickness（ IMT）,plaque size,plaque thickness changes were compared between two groups. Results After6 months of treatment,the 24 h SBP,24 h DBP and 24 h MAP in observation group were（ 125. 6 ± 6. 5）,（ 73. 7 ± 5. 5）,（ 68. 5 ± 5. 6） mm Hg,which were significantly lower than control group[（ 130. 4 ± 8. 6）,（ 78. 4 ± 6. 2）,（ 73. 9 ± 6. 3） mm Hg,P〈0. 05]. The patch thickness,length diameter and IMT in observation group were（ 1. 51 ± 0. 64）,（ 5. 85 ± 2. 24）,（ 0. 92 ± 0. 06） mm,which were significantly lower than control group[（ 1. 76 ± 0. 52）,（ 6. 83 ±2. 06）,（ 0. 95 ± 0. 07） mm,P〈0. 05]. The TG,TC and LDL-C in observation group were significantly lower than tcontrol group,HDL-C was significantly higher than control group（ P〈0. 05）. Conclusion Amlodipine combined with valsartan could significantly improve blood pressure control and effectively reverse the lesion of carotid artery atherosclerosis in patients with primary hypertension with no serious adverse reactions.
出处
《中国生化药物杂志》
CAS
2016年第1期157-159,162,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
高血压
氨氯地平
缬沙坦
动脉硬化病变
临床疗效
hypertension
amlodipine
valsartan
atherosclerotic lesion
clinical effect
