摘要
目的:观察黄体支持时加用滋肾育胎丸对体外受精—胚胎移植(IVF-ET)周期胚胎着床和妊娠结局的影响。方法:行IVF-ET助孕符合纳入标准的不孕症患者共580例,随机分为对照组220例和研究组各360例,对照组予常规西药黄体支持,研究组加服滋肾育胎丸。结果:研究组和对照组临床妊娠率分别为58.06%和47.27%(P<0.05);着床率分别为33.13%和25.76%(P<0.01);早期先兆流产发生率分别为15.79%和25.53%(P<0.05);流产发生率分别为9.09%和13.46%(P>0.05);抱婴回家率分别为51.7%和40.45%(P<0.01)。结论:黄体支持时加用滋肾育胎丸可提高IVF-ET周期的胚胎着床率、临床妊娠率和抱婴回家率,降低先兆流产发生率。对流产发生也有降低趋势,但由于流产样本量较少,差异尚无统计学意义,需更大样本的研究。
Objective： To observe the effect of Zishen Yutai pill on embryo implantation and pregnancy outcome in luteal phase of cycles undergoing in vitro fertilization and embryo transfer. Methods： 580 patients who met the inclusion criteria were randomly divided into study group（n=360） and control group（n=220）. The patients in control group received regular luteal support,and the patient in study group received oral Zishen Yutai pill besides regular luteal support. Results： study group vs. control group： The rate of clinical pregnancy is 58.06% vs. 47.27%（P〈0.05）;Embryo implantation rate is 33.13% vs. 25.76%（P〈0.01）;The rate of threatened abortion is 15.79% vs. 25.53%（P〈0.05）;The rate of abortion is 9.09% vs. 13.46%（P〉0.05）;The rate of take home baby is 51.7% vs. 40.45%（P〈0.01）.Conclusions：The using of Zishen Yutai pill in luteal phase in IVF-ET cycles increased the embryo implantatio n rate,th e rate of clinical pregnancy and the rate of take home baby,as well as decreased the rate of threatened abortion. The rate of abortion was also decreased,but there is no significant difference because of the small sample of abortion. A study with bigger sample is expected in future.
出处
《中医药临床杂志》
2016年第2期209-212,共4页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金(NO.81373671,NO.81370757)
韩明向全国名老中医药专家传承工作室基金
关键词
滋肾育胎丸
黄体支持
胚胎着床
妊娠结局
Zishen Yutai pill
luteal support
embryo implantation
pregnancy outcome
