摘要
目的探究与分析活血化瘀法治疗溃疡性结肠炎的临床效果。方法选取我院自2013年9月—2015年9月收治的80例溃疡性结肠炎患者,采取随机数字表法分为西药组与中药组,每组各40例,西药组给予口服美沙拉嗪片,中药组给予活血化瘀中药汤剂,对比2组患者的临床疗效、主要症状消失时间、血清TNF-α、IL-6及IL-8的变化。结果西药组的总有效率为75.00%,中药组的总有效率为92.50%,中药组的总有效率明显高于西药组,差异有统计学意义(P<0.05)。中药组较西药组相比腹痛、腹泻、脓血便消失时间均明显缩短,具有统计学意义(P<0.05)。西药组与中药组治疗前血清TNF-α、IL-6及IL-8水平差异无统计学意义(P>0.05)。西药组与中药组治疗后较治疗前相比血清TNF-α、IL-6及IL-8水平均明显降低,中医药治疗后较西药组治疗后相比血清TNF-α、IL-6及IL-8水平下降更加显著(P<0.05)。结论活血化瘀法可通过调节血小板的抑制作用对免疫炎症反应过程进行调节,从而减少对血管内皮的刺激,改善高凝状态和血清炎性指标,行气开郁,活血止痛,用于治疗溃疡性结肠炎疗效显著。
Objective To explore the blood circulation by removing blood stasis method and analysis of clinical effect for the treatment of ulcerative colitis. Methods Select our hospital from September 2013 to September 2015 were treated 80 cases of patients with ulcerative colitis,take a random number table method was divided into western medicine and Chinese medicine group,40 cases in each group,The western medicine group was given oral beauty salad lamictal tablets,Chinese traditional medicine group was given the medicinal broth of TCM for activating blood circulation and compared the clinical efficacy of two groups of patients,the main symptoms disappear time,serum TNF alpha,the change of IL-6 and IL-8. Results The total effective rate was 75. 00%,western medicine group,Chinese medicine group total effective rate was 92. 50%,total effective rate of traditional Chinese medicine group was obviously higher than that of western medicine group,with significant difference（ P〈0. 05）. Chinese traditional medicine than western medicine group compared with abdominal pain,diarrhea,purulent blood disappears time were significantly shortened,with statistical significance（ P〈0. 05）. Western medicine and Chinese medicine group before treatment the serum TNF alpha,IL-6 and IL 8 level no obvious difference（ P〉0. 05）. Western medicine and Chinese medicine group after treatment was compared with the serum TNF alpha,IL- 6 and IL 8 levels were significantly lower,after treatment of Chinese medicine with western medicine group after treatment compared with the serum TNF alpha,IL-6and IL 8 levels drop more significantly（ P〈0. 05）. Conclusion Method for activating blood circulation can be adjusted by platelet inhibitory effect on the immune inflammatory reaction process adjustment,so as to reduce the stimulus for the vascular endothelium,improve high coagulation state and serum inflammatory index,qi yu,invigorate the circulation of the pain,has a good effect for the treatment of ulcerative colitis.
出处
《吉林中医药》
2016年第3期274-277,共4页
Jilin Journal of Chinese Medicine
基金
陕西省科技攻关项目(2000K14-G15)
关键词
活血化瘀法
溃疡性结肠炎
血清学指标
promoting blood circulation to remove blood stasis method
ulcerative colitis
serological indicator
