摘要
目的探究伊立替康联合顺铂方案对宫颈癌患者血清B淋巴细胞瘤-2基因(B-cell lymphoma-2,Bcl-2)和结肠癌转移相关基因1(metastasis-associated in colon cancer 1,MACC1)蛋白的影响。方法收集南昌市第三人民医院妇产科接受宫颈癌手术患者92例,随机分为对照组和治疗组。对照组采用紫杉醇疗法实施化疗方案,对照组患者实施伊立替康联合顺铂方案,比较2组患者临床疗效以及血清Bcl-2及MACC1蛋白情况。结果治疗前2组患者Bcl-2、MACC1水平比较无统计学意义;治疗后2组患者血清Bcl-2、MACC1蛋白含量降低(P<0.05),与对照组治疗后相比,治疗组患者血清Bcl-2、MACCI蛋白含量较低(P<0.05);随访中,半年内治疗组和对照组分别死亡5例和6例,存活率分别为89.13%和86.96%(χ2=0.103,P>0.05),1年内治疗组和对照组分别死亡4例和12例,存活率分别为91.30%和73.91%(χ2=4.84,P<0.05)。结论伊立替康联合顺铂方案治疗宫颈癌1年的存活率较高,其可能与降低血清Bcl-2及MACC1蛋白含量有关。
Objective To investigate effect of irinotecan combined with cisplatin on level of Bcl-2 and MACC1 protein in serum in patients with cervical cancer. Methods 92 cases of patients with cervical cancer surgery from department of gynaecology and obstetrics,the third People＇s hospital of Nanchang were randomly divided into control group and treatment group. Control group was treated with paclitaxel therapy chemotherapy,treatment group were treated with irinotecan combined with cisplatin. Bcl-2 and MACC1 protein in serum were compared before and after the treatment.Results The level of Bcl-2 and MACC1 in both groups were not statistically significant pre-treatment; After treatment,the levels of Bcl-2 and MACC1 protein in serum were decreased（ P〈0. 05）. Compared with control group post-treatment,the level of Bcl-2 and MACC1 protein in serum were lower in treatment group（ P〈0. 05）. During follow-up,death cases of treatment group and control group were 5 cases and 6 cases respectively,the survival rate of 89. 13% and 86. 96% respectively within the past six months（ χ2= 0. 103,P〈0. 05）. Death cases of treatment group and control group were 4 cases and 12 cases respectively. the survival rate of 91. 30% and 73. 91% respectively within one year（ χ2= 4. 84,P〈0. 05）Conclusion Irinotecan combined with cisplatin in the treatment of cervical cancer in one year survival rate is higher,which may be related to the decrease of serum levels of Bcl-2 and MACC1 protein content.
出处
《中国生化药物杂志》
CAS
2015年第12期94-96,共3页
Chinese Journal of Biochemical Pharmaceutics
