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胰岛素样生长因子通路在肿瘤发生中作用的研究进展 被引量：3

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摘要 胰岛素样生长因子(IGF)信号通路属于人类进化过程中保守的信号通路,在调节胚胎分化和个体发育及正常生理活动中有着极为重要的意义,已经明确许多疾病如糖尿病、胰岛素抵抗、内分泌紊乱等与IGF通路中一种或多种蛋白的异常密切相关。近年来,越来越多的肿瘤性疾病被发现与这条通路密切相关,如肺癌、肝癌、血液系统肿瘤等,其肿瘤发生机制可能是通过结合IR、IGF-1R或IR-IGF-1R杂合受体,激活PI3K/Akt信号通路而发挥各种生物学作用。
作者 赵浩然
机构地区 中国医科大学
出处 《山东医药》 CAS 北大核心 2016年第6期102-104,共3页 Shandong Medical Journal
关键词 胰岛素样生长因子 胰岛素样生长因子结合蛋白 恶性肿瘤 白血病
分类号 R730.2 [医药卫生—肿瘤]
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参考文献29

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二级参考文献66

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共引文献11

同被引文献27

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二级引证文献9

山东医药
2016年 第6期

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