摘要
目的：探讨米非司酮配伍米索前列醇治疗稽留流产的临床疗效及安全性。方法将184例稽留流产患者按照数字表法随机分为研究组和对照组，每组各92例，其中对照组给予口服己烯雌酚后行清宫术，而研究组则在给予米非司酮配伍米索前列醇治疗后行清宫术，比较两组患者的临床治疗效果及不良反应发生情况。结果研究组在用药后流产有效率为95．65％，明显高于对照组的86．96％，差异有统计学意义（χ^2＝4．38，P ＜0．05）。与对照组比较，研究组手术时间[（7．22±1．11）min]明显缩短，术中出血量[（35．68±5．62）mL]明显下降，妊娠物自然排出率（81．52％）明显提高，人工流产综合征发生率（3．26％）及再次清宫率（5．43％）则明显下降，且差异有统计学意义（t ＝16．10、12．52，χ^2＝7．84、8．87、15．93，均 P ＜0．05）。研究组不良反应发生率为16．30％，明显低于对照组的29．35％，差异有统计学意义（χ^2＝4．44，P ＜0．05）。结论米非司酮配伍米索前列醇使用，起到相辅相成的作用，在有效提高治疗稽留流产的疗效同时，手术情况良好，而且减少了患者的不良反应和并发症，减轻了患者的痛苦，值得临床推广。
Objective To explore the clinical efficacy and safety of mifepristone combined with misoprostol in the treatment of missed abortion.Methods According to the digital table,184 patients with missed abortion were randomly divided into study group and control group,92 cases in each group.The control group was given oral diethyl-stilbestrol underwent curettage,while the study group was given mifepristone combined with misoprostol therapy under-went curettage.The clinical therapeutic effect and adverse reaction were compared between the two groups.Results The effective rate of the study group after treatment was 95.65%,which was significantly higher than 86.96% of the control group,the difference was statistically significant（χ^2 =4.38,P 〈0.05）.Compared with the control group,in the study group,the operative time[（7.22 ±1.11）minute]observed significant relationship,intraoperative hemorrhage volume[（35.68 ±5.62）milliliter]decreased significantly,pregnancy natural rate of discharge（81.52%）was obvi-ously improved,artificial abortion syndrome incidence rate（3.26%）and again the rate of curettage（5.43%）was obviously decreased,and the differences were statistically significant（t =16.10,12.52,χ^2 =7.84,8.87,15.93,all P 〈0.05）.The clinical adverse reaction rate in the study group was 16.30%,which was significantly lower than 29.35% in the control group,the difference was statistically significant（χ^2 =4.44,P 〈0.05）.Conclusion Mife-pristone combined with misoprostol plays a complementary role,can improve the treatment of missed abortion and has good operation condition.It also can reduce the adverse reactions,complications and pain of patients.It is worth of clinical promotion.
出处
《中国基层医药》
CAS
2016年第4期577-580,共4页
Chinese Journal of Primary Medicine and Pharmacy
