摘要
【目的】观察加味补阳还五汤治疗缺血性脑卒中后抑郁症(PSD)的临床疗效。【方法】将80例患者随机分为治疗组36例和对照组44例。治疗组脱落1例,对照组脱落6例。最终治疗组35例、对照组38例纳入研究。2组均给予脑卒中Ⅱ级预防基础治疗,治疗组同时给予加味补阳还五汤内服治疗,对照组同时给予西药盐酸帕罗西汀片治疗,疗程均为4周。于治疗前和治疗后第1、2、4周末分别采用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和不良反应。【结果】(1)治疗组与对照组临床疗效比较,差异无统计学意义(P>0.05)。(2)治疗后,2组患者HAMD量表评分均显著降低(P<0.05或P<0.01)。在治疗1、2周末,治疗组的降低作用优于对照组(P<0.05或P<0.01),但在治疗4周末,2组的降低作用差异无统计学意义(P>0.05)。(3)治疗组对副反应的干预作用优于对照组(P<0.05)。【结论】加味补阳还五汤治疗脑卒中后抑郁症起效快、疗效稳定、不良反应少、安全性高、依从性好。
Objective To observe the clinical effects of modified Buyang Huanwu decoction（BHD）for the treatment of post-stoke depression（PSD）. Methods A total of 80 cases of PSD patients were randomly divided into Chinese medicine group（36 cases）and western medicine group（44 cases）. In the end, one case of Chinese medicine group and 6 cases of western medicine group were dropped out,and the final case sample was 35,38 in Chinese medicine group and western medicine group, respectively. Both groups were treated with secondary preventive measures for stroke, and additionally, Chinese medicine group was given oral use of BHD and western medicine group was given oral use of paroxetine. The treatment course covered 4 weeks. Hamilton Depression Rating Scale（HAMD） and treatment emergent symptom scale（TESS） were used for scoring to evaluate the efficacy and adverse reaction respectively before treatment and at the end of treatment week1,2,4. Results（1）There was no significant difference of clinical efficacy between Chinese medicine group and western medicine group（65.7% vs 55.3%, P〈0.05）.（2）After treatment, the HAMD scores of the two groups were decreased significantly（P〈0.05 or P〈0.01 compared with those before treatment）. The decrease at the end of treatment week 1 and 2 in Chinese medicine group was superior to that in western medicine group（P〈0.05 or P〈0.01）, but at the end of treatment week 4,the differences of the HAMD scores between the two groups were insignificant（P〈0.05）.（3）The intervention of side effects of Chinese medicine group was better than that of western medicine group（P〈0.05）. Conclusion Modified BHD is effective and safe for the treatment of PSD,with the advantages of fast-acting,stable curative effect,less adverse reaction,and high safety and good compliance.
出处
《广州中医药大学学报》
CAS
2016年第2期163-166,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广西医疗卫生适宜技术研究与开发项目(编号:S201407-03)
广西高校科学技术研究项目(编号:YB20142743)
广西医药卫生计划项目(编号:Z2014320)
桂林市科学研究与技术开发项目(编号:20140120-1-8)
关键词
扶阳固本
加味补阳还五汤
脑卒中后抑郁症
HAMD
TESS
supporting Yang and strengthening body resistance
Buyang Huanwu decoction
post-stroke depression
HAMD
TESS
