摘要
目的:探讨布地奈德雾化吸入联合暖肺祛瘀汤治疗慢性阻塞性肺疾病(COPD)急性发作期临床疗效。方法:研究对象选取医院2013年1月—2015年5月收治COPD急性发作期患者共170例,以随机抽签法分为对照组(85例)和联合组(85例),分别采用布地奈德雾化吸入单用和在此基础上加用暖肺祛瘀汤辅助治疗;比较两组患者临床疗效,治疗前后中医证候积分、FEV1/FVC、FEV1%预计值、TNF-α及IL-8水平等。结果:对照组和联合组患者临床治疗总有效率分别为82.35%(70/85),96.47%(82/85);联合组患者临床疗效显著优于对照组,差异具有显著性(P<0.05);对照组患者治疗前后中医证候积分分别为(14.80±2.82)分,(7.95±1.42)分;联合组患者治疗前后中医证候积分分别为(14.64±2.76)分,(4.24±0.70)分;联合组患者治疗后中医证候积分显著优于治疗前、对照组,差异具有显著性(P<0.05);对照组患者治疗前FEV1/FVC和FEV1%预计值分别为(49.85±3.50)%,(53.40±8.85)%;对照组患者治疗后FEV1/FVC和FEV1%预计值分别为(57.14±4.41)%,(64.44±10.51)%;联合组患者治疗前FEV1/FVC和FEV1%预计值分别为(50.03±3.57)%,(53.53±8.92)%;联合组患者治疗后FEV1/FVC和FEV1%预计值分别为(65.53±5.94)%,(70.83±12.94)%;联合组患者治疗后FEV1/FVC和FEV1%预计值均显著高于对照组、治疗前,差异具有显著性(P<0.05);对照组患者治疗前TNF-α和IL-8水平分别为(64.33±5.24)ng/L,(78.24±8.60)ng/L;对照组患者治疗后TNF-α和IL-8水平分别为(58.87±4.40)ng/L,(70.71±6.92)ng/L;联合组患者治疗前TNF-α和IL-8水平分别为(64.28±5.19)ng/L,(77.97±8.48)ng/L;联合组患者治疗后TNF-α和IL-8水平分别为(51.45±2.78)ng/L,(62.54±4.45)ng/L;联合组患者治疗后TNF-α和IL-8水平均显著低于对照组、治疗前,差异具有显著性(P<0.05)。结论:布地奈德雾化吸入联合暖肺祛瘀汤治疗COPD急性发作期可有效改善临床症状体征,增强肺部通气功能,并有助于降低气道炎症�
Objective： To investigate the clinical effects of budesonide inhalation combined with Nuanfeiquyu Decoction in the treatment of acute exacerbation of COPD. Methods： A total of 170 patients with acute exacerbation of COPD were chosen from January 2013 to May 2015 in our hospital and randomly divided into control group（ 85 patients） with budesonide inhalation and combination group（ 85 patients） with Nuanfeiquyu Decoction on the basis of control group and the clinical effects,the TCM syndromes scores,values of FEV1% and FEV1 / FVC,levels of TNF- α and IL- 8 before and after treatment of both groups were compared. Results： The clinical total effects of control and combination groups were separately 82. 35%（ 70 /85） and 96. 47%（ 82 /85） and the clinical effects of combination group was significantly better than that of the control group（ P〈0. 05）. The TCM syndromes scores before and after treatment of control group were separately（ 14. 80 ± 2. 82） points and（ 7. 95 ± 1. 42） points and those of combination group separately（ 14. 64 ± 2. 76）points and（ 4. 24 ± 0. 70） points. The combination group＇s were significantly better than the control group＇s（ P〈0. 05）.The values of FEV1% and FEV1 / FVC before treatment of control group were separately（ 49. 85 ± 3. 50） % and（ 53. 40± 8. 85） % and those of the combination group separately（ 57. 14 ± 4. 41） % and（ 64. 44 ± 10. 51） %. The values ofFEV1% and FEV1 / FVC after treatment of control group were separately（ 50. 03 ± 3. 57） % and（ 53. 53 ± 8. 92） % and those of the combination group separately（ 65. 53 ± 5. 94） % and（ 70. 83 ± 12. 94） %. The combination group＇s were significantly better than the control group＇s and those before treatment（ P〈0. 05）. The levels of TNF- α and IL- 8 before treatment of the control group were separately（ 64. 33 ± 5. 24） ng / L and（ 78. 24 ± 8. 60） ng / L and those after treatment separately（ 58. 87 ± 4. 40） ng / L and（ 70. 7
出处
《中华中医药学刊》
CAS
北大核心
2016年第3期690-692,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生科技计划重点学科平台项目(2011ZDA027)
