摘要
目的比较观察早期巨块型宫颈癌新辅助化疗中静脉给药途径和动脉给药途径的疗效和毒副反应。方法入组19例Ib2期宫颈癌行新辅助化疗患者,比较观察行静脉化疗(11例)和动脉化疗(8例)患者在疗效和毒副反应上的差异。结果 2组总有效率比较差异无统计学意义(P>0.05),但静脉化疗组总有效率稍低于动脉化疗组。2组毒副反应发生率比较差异无统计学意义(P>0.05),但静脉化疗组局部疼痛发生率稍低于动脉化疗组。结论对于早期巨块型宫颈癌,新辅助化疗经静脉给药和经动脉途径给药均可有效缩小肿瘤体积,经静脉途径给药简便,易行,安全,对防止盆腔淋巴结及远处转移更有效;经动脉给药需血管介入技术,费用略高,理论上总有效率优于静脉给药,是一种很好的给药方式。
Objective To compare the therapeutic effect and toxicities of arterial perfusion or intravenous injection neoadjuvant chemotherapy in the treatment of bulky early-stage cervical cancer. Methods The 19 patients with Ⅰb2bulky cervical cancer were divided into two groups： the intravenous injection group（ 11 patients） and the arterial perfusion group（ 8 patients）,the therapeutic effect and toxicities of the two groups were compared. Results The response rate of the intravenous injection group was lower than that of the arterial perfusion group,but there was no statistical difference between the two groups（ P 〉0. 05）. The local pain incidence of the intravenous injection group was lower than that of the arterial perfusion group,but there was no statistical difference between the two groups（ P 〉0. 05）. Conclusion For bulky early-stage cervical cancer patients,neoadjuvant chemotherapy was effective in reducing bulky,whether though arterial perfusion or intravenous injection,the way of intravenous injection was easy,safe and handy to operate; the way of arterial perfusion needs vascular intervention technique,the effective rate would be higher in theory,it is an effective method.
出处
《肿瘤基础与临床》
2016年第1期45-47,共3页
journal of basic and clinical oncology
关键词
宫颈癌
新辅助化疗
给药途径
cervical cancer
neoadjuvant chemotherapy
administration route
