摘要
目的观察分析替吉奥单药作为老年或体弱转移性结直肠癌（m CRC）患者治疗方案的疗效和毒副反应。方法 24例老年或体弱m CRC患者接受口服替吉奥治疗,即替吉奥35 mg·m-2,每天2次,连用2周,停药1周。观察其近期疗效、疾病无进展生存期、总生存期、毒副反应等。结果全组24例患者的总有效率为16.7%,疾病控制率为75.0%;中位无进展生存期为4.1（95%CI为2.8~5.4）个月,中位总生存期：12.3（95%CI为9.9~14.7）个月;主要毒副反应为胃肠道反应、骨髓抑制,多为轻度,无患者因毒副反应终止治疗。结论替吉奥单药治疗老年或体弱m CRC患者安全性高、疗效好。
Objective To evaluate the efficacy and toxicities of S-1 monotherapy in the treatment of elderly or frail patients with metastatic colorectal cancer. Methods A total of 24 elderly or frail patients with metastatic colorectal cancer were eligible for S-1 of 35 mg·m- 2given twice daily for 2 weeks followed by 1 week of rest. The shortterm effects,progression-free survival,overall survival time,toxicities were observed. Results The overall response rate of all the 24 patients was 16. 7%,the disease control rate was 75. 0%. The median progression-free survival was4. 1 months（ 95% CI 2. 8-5. 4 months）,the median overall survival was 12. 3 months（ 95% CI 9. 9-14. 7months）. The main toxicities were gastrointestinal reactions and bone marrow suppression,none of the patients terminated treatment due to toxicities. Conclusion S-1 monotherapy was well-tolerated and efficacious in the treatment of elderly or frail patients with metastatic colorectal cancer.
出处
《肿瘤基础与临床》
2016年第1期39-42,共4页
journal of basic and clinical oncology
关键词
替吉奥
老年患者
体弱患者
转移性结直肠癌
S-1
elderly patients
frail patients
metastatic colorectal cancer
