摘要
目的:了解我院住院患者二甲双胍使用情况,总结二甲双胍的不合理用药现象,促进临床合理用药。方法:收集2014年应用二甲双胍的住院患者病历,对二甲双胍临床应用的适应证、用法用量、禁忌证、不良反应及药物相互作用等进行系统的回顾性调查分析。结果:二甲双胍主要应用于2型糖尿病患者。使用最多的剂型为缓释片,约占65.17%。二甲双胍用药不合理率为38.87%,其中用法用量不合理59.83%、存在用药禁忌39.3%和无适应证用药0.87%。用法用量不合理主要表现为肠溶片餐中或餐后服用,占83.45%。二甲双胍的应用禁忌证主要为应用碘造影剂前后未停用二甲双胍(47.47%),肝、肾功能不全(21.21%)。二甲双胍的不良反应发生率为6.98%。结论:目前二甲双胍在临床应用中仍存在一些不合理现象,应积极开展二甲双胍临床药学服务,加强其合理用药,降低临床用药风险。
Objective： To investigate the clinical application of Metformin in patients of the hospital,analysing the problem in use of metformin,summarizing the irrational phenomenon of medication. And to promote the rational use of metformin and reduce the risk of clinical medication. Methods： The cases history with metformin in the hospital between January and December,2014 were consulted,to retrospective analyze the indication,dosage,contraindication,adverse drug reaction,and drug interaction of metformin systematically. Results： The common clinical indications for metformin use were type 2 diabetes mellitus. The main consumption in dosage form of metformin was sustained release tablet,the rate was about 65. 17%. The irrational use of metformin accounted for 38. 87%,the biggest irrational phenomenon was the mistake of usage and dose 59. 83%,existing contraindication was 39. 3%,and without indication was 0. 87%. The unreasonable usage and dosage of metformin was enteric- coated tablets were taken during or after a meal,the rate was 83. 45%. The main contraindication of metformin was that metformin were still taken before or after the application of iodine contrast agent47. 47%. And the cases history of liver and renal insufficiency was about 21. 21%. 6. 98% of the patients happened adverse reaction,mainly including hypoglycemia and gastrointestinal reaction. Conclusion： At present,the clinical application of metformin was still deficient,we should actively carry out clinical pharmacy services of metformin,and to promote the rational use of metformin,reduce the risk of clinical medication.
出处
《药物流行病学杂志》
CAS
2016年第3期163-166,共4页
Chinese Journal of Pharmacoepidemiology
基金
福建中医药大学附属第二人民医院院内课题资助项目(编号:YNP201408)
关键词
二甲双胍
临床应用
合理用药
Metformin
Clinical Application
Rational drug use
