期刊文献+

慢性乙型肝炎患者经恩替卡韦治疗的临床效果探讨 被引量:4

下载PDF
导出
摘要 目的对应用恩替卡韦治疗慢性乙型肝炎患者的临床效果进行探讨。方法对收治的慢性乙型肝炎患者中随机抽取70例进行研究,并按照随机数字表法将他们分成两组,并不同的药物治疗。其中对照组35例应用拉米夫定治疗,观察组35例则应用恩替卡韦治疗,将两组患者的治疗效果和血清HVB DNA和ALT的转阴率进行对比。结果对照组共有25例(71.43%)达到显效和有效标准,观察组共有32例(91.43%)达到显效和有效标准,组间总有效率比较,观察组高于对照组,差异显著(P<0.05)。同时,对照组患者的血清HVB DNA和血清ALT的转阴率分别为51.43和62.86%,低于观察组的85.71%和94.29%,组间差异显著(P<0.05)。结论应用恩替卡韦治疗慢性乙型肝炎可以显著提高治疗效果,并能有效预防病毒感染,安全性较高。
作者 郭金龙
出处 《航空航天医学杂志》 2016年第2期223-224,共2页 Journal of Aerospace medicine
  • 相关文献

参考文献4

二级参考文献77

共引文献86

同被引文献34

  • 1Mustafa Kemal C,Tuba D, Celal A, et al. Four-year study of entecavir efficacy and safety in nucleos (t)ide-naive HBeAg positive chronic hepatitis B patients[J]. Acta Clinica Croatica,2014,53(1) :31-36. 被引量:1
  • 2Yang SC, Lee CM, Hu TH, et al. Virological response to entecavir re- duces the risk of liver disease progression in nucleos (t) ide analogue- experienced HBV-infected patients with prior resistant mutants [ J ]. Journal of Antimicrobial Chemotherapy ,2013,68 ( 9 ) :2154-2163. 被引量:1
  • 3Ahn J, Lee HM, Lim JK, et al. Entecavir safety and effectiveness in a national cohort of treatment-naYve chronic hepatitis B patients in the US-the ENUMERATE study [ J 1. Alimentary Pharmacology & Thera- peutics,2015,43 ( 1 ) : 134-144. 被引量:1
  • 4Tsai MC, Chen CH, Hung CH, et al. A comparison of efficacy and safe- ty of 2-year telbivudine and entecavir treatment in patients with chron- ic hepatitis B:a match-control study [ J ]. Clinical Microbiology and In- fection ,2014,20 ( 2 ) :90-100. 被引量:1
  • 5Wiens A, Lenzi L, Venson R, et al. Comparative Efficacy of Oral Nu- cleoside or Nucleotide Analog Monotherapy Used in Chronic HepatitisB : A Mixed-Treatment Comparison Meta-analysis [ J ]. Phannacothera- py : The Journal of Human Pharmacology and Drug Therapy, 2013,33 (2) :144-151. 被引量:1
  • 6Toy M, Hutton DW, So SK, et al. Cost-Effectiveness and Cost Thresh- olds of Generic and Brand Drugs in a National Chronic Hepatitis B Treatment Program in China[ J]. Plos One,2015,10( 11 ) :526-535. 被引量:1
  • 7Wiens A, Lenzi L, Venson R, et al. Economic evaluation of treatments for chronic hepatitis B [ J]. The Brazilian Journal of Infectious Disea- ses,2013,17(4) :418-426. 被引量:1
  • 8Wang G, Liu Y, Qiu P, et al. Cost-effectiveness analysis of lamivudi- ne, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance [ J ]. Drug design, development and thera- py,2015,12(9) :2839-2846. 被引量:1
  • 9Preda CM, Baicus C, Negreanu L, et al. Effectiveness of entecavir treatment and predictive factors for virologic response [ J ]. Revista Espanola De Enfermedades Digestivas Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 2014,106 ( 5 ) :305-311. 被引量:1
  • 10Gines PP, Lenz K, Moiler S, et al. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis [ J]. Journal of Hepatology,2010, 53(3) :397-417. 被引量:1

引证文献4

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部