摘要
目的探讨帕金森病（PD）伴慢性疼痛患者的临床特征及其与认知功能的相关性。方法选择100例PD伴慢性疼痛患者为研究对象（观察组）。选择同期PD不伴慢性疼痛患者100例为疾病对照组。选择伴疼痛的健康者90例为对照组。分析PD伴疼痛患者的临床特征及与认知功能的关系。结果100例PD伴慢性疼痛患者骨骼肌疼痛42例（42．0％），运动障碍性疼痛23例（23．0％），神经根性痛23例（23．0％），中枢性疼痛9例（9．0％），静坐不能3例（3．0％）；对照组伴慢性疼痛患者疼痛部分主要位于头颈部和腰部，PD伴慢性疼痛患者疼痛部位主要位于四肢，两组头颈痛、腰部痛、四肢痛发生率有统计学差异（x2=10．017、4．990、21．770，均P〈0．05）；观察组日常生活、情绪、行走能力、正常工作、睡眠、生活乐趣方面评分均优于对照组，有统计学意义（t=7．021、7．011、3．167、7．016、7．014、8．036，均P〈0．05）；PD伴疼痛组和PD不伴疼痛组在UPDRS评分、H-Y分期、HAMD评分、PDQL评分、LED方面比较有统计学意义（t=5．791、5．821、5．271、5．809、5．267、5．902、5．961、2．721，均P〈0．05），PD伴疼痛组发生嗅觉障碍、异动症的比例高于PD不伴疼痛组，有统计学意义（x2=5．307、4．880，均P〈0．05）；PD伴疼痛组患者命名能力评分、延迟回忆低于PD不伴疼痛组，差异有统计学意义（t=-1．689、-1．561，均P〈0．05），PD伴疼痛组和PD不伴疼痛组患者在MoCA总分及其他项目评分方面比较无统计学意义（t=-0．967、-0．272、-0．791、-0．837、-0．671、-0．658，均P〉0．05）。结论PD伴慢性疼痛以骨骼肌疼痛为主，PD伴慢性疼痛的疼痛部位与正常人不同，PD伴慢性疼痛对患者日常生活、睡眠质量、抑郁等不良情绪的产生均有影响，PD伴慢性疼痛的发生与患者抑郁、认知功能障碍密切相关，�
Objective To study ehnical features of patients with Parkinson~ disease （PD） with chronic pain and its correlation with cognitive function. Methods 100 PD patients with chronic pain were selected as the observa- tion group. 100 PD patients without chronic pain were selected as disease control group. 90 healthy subjects with pain were selected as control group. Statistical and clinical features of PD patients with pain, and the relationship between cognitive function were made. Results 100 patients with chronic pain with PD skeletal muscle pain in 42 cases （42. 0% ）, motility pain in 23 cases （23.0%）,23 cases of nerve root pain （23.0%）,9 cases of central pain （9. 0% ）, akathisia in 3 patients （3.0%） ;Control pain in patients with chronic pain with part mainly in the head and neck and the waist, PD patients with chronic pain with mainly in the limbs, pain in the two groups the incidence of head and neck pain,waist pain, hmb pain had statistical differences （X2 = 10. 017,4. 990,21. 770, all P 〈 0.05 ） ; Observation group of daily life, emotion, ability to walk, normal work, sleep, life fun scores were better than those in control group, with statistical significance （ t = 7. 021,7.011,3. 167,7. 016,7. 014,8. 036, all P 〈 0.05 ） ; PD with pain group and PD without pain in gender, age, course of the disease symptoms, PD with pain group and PD without pain in UPDRS score, H ~ Y in instaUment, HAMD scores, PDQL score, LED aspects comparison was statistically significant （~2 = 5. 307,4.880, all P 〈 0.05 ）, PD with pain group smell disorders, motion sickness were higher than the proportion of the PD without pain group,with statistical significance （t = - 1. 689, - 1. 561 ,all P 〈0.05） ;PD patients with pain group named ability score, delayed recall below PD without pain group, the difference Was statistically significant （P 〈 0.05 ）, PD patients with pain and PD without pain group in the MoCA scores and other project score had no statistical significance （t = - 0. 96
出处
《中国基层医药》
CAS
2016年第3期423-427,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
帕金森病
慢性疼痛
临床特征
认知功能
相关性
Parkinson＇s disease
Chronic pain
Clinical features
Cognitive function
The correlation
