摘要
目的探讨尿微量清蛋白与尿肌酐比值（UACR）与急性缺血性脑卒中（AIS）患者病情严重程度及近期预后的相关性。方法选取112例AIS患者为研究对象，检测患者入院时的UACR及相关实验室检查指标，记录美国国立卫生院卒中量表（NIHSS）评分，以及入院28d后的改良Rkin量表（mRS）预后评分情况；比较NIHSS 5分及NIHSS〈5分、不同UACR水平以及不同预后分组之间患者观察指标的差异。结果NIHSS≥5分组的患者中入院时UACR水平[（15．41±3．21）m∥g]高于NIHSS〈5分患者的[（9．52±2．04）mg／g]（t=12．214，P〈0．001）；UACR≥11．60mg／g分组的患者中的NIHSS5分的比例（87．5％）、mRS评分〉2分的比例（82．1％）、近期死亡患者的比例（23．2％）高于UACR〈11．60m∥g分组的比例（分别为32．1％、25．O％、7．1％；x2值分别为33．509、34．476、5．598，均P〈0．05）；mRS评分〉2分组中患者UACR水平[（16．10±3．29）m∥g]高于mRS评分≤2分患者[（8．38±1．95）mg／g]（t=20．132，P〈0．001）；Pearson相关分析显示：UACR水平与NIHSS评分（r=0．412，P〈0．050）、高敏G反应蛋白hs—CRP（r=0．473，P〈0．050）、白细胞计数（WBC）（r=0．442，P〈0．050）、空腹血糖（FPG）（r=0．375，P〈0．050）呈正相关。多因素Logistic回归分析显示：UACR（OR=1．587，P〈0．050）是AIS患者近期预后不良的独立危险因素。结论UACR与AIS患者的病情严重程度及近期预后密切相关，高水平UACR可能是AIS患者近期预后不良的独立危险因素。
Objective To explore the correlation of urine albumin and creatinine ratio（UACR） and short - term prognosis in patients with acute ischemic stroke （AIS）. Methods 112 patients With AIS were selected as the research subjects. The admissioti UACR and related laboratory examination indexes were detected, the US national institutes of health stroke scale （NIHSS） scores, and 28 d after admission of the modified Rankin scale （mRS） prognostic score were recorded. The NIHSS 5 or more points and NIHSS 〈 5 points, different levels and UACR patient observation index between the different prognosis group were compared. Results NIHSS 5 or more group of patients on admission UACR level[ （ 15.41 ±3.21 mg/g） ] was higher than the NIHSS 〈 5 patients （9.52 ± 2.04） mg/g （ t = 12. 214 ,P 〈 0.001 ） ; UACR acuity 11.60mg/g group in NIHSS of 5 or more proportion of patients （87.5%）, mRS score 〉 2 points （ 82.1% ）, the proportion of the recent death patients （ 23.2% ） than the proportion of UACR 〈 11.60mg/g, the proportion of the group （ 32.1% ,25.0% ,7.1% ; the chi - square values 33. 509,34. 476,5. 598, all P 〈0.050） ;MRS score 〉2 groups of patients UACR level[ （16.10 ± 3.29）mg/g] was higher than that in patients with mRS score 2 points or less （8.38 ± 1.95 ） rag/g（ t = 20. 132, P 〈 0. 001 ） ; Pearson correlation analysis showed that the standard of UACR and NIHSS score （ r = 0. 412, P 〈 0. 05 ）, high - sensitivity C - reactive protein （ hs - CRP） （ r= 0.473, P 〈 0.050 ）, white blood celt count （WBC） （ r = 0. 442, P 〈 0. 050 ）, fasting plasma glucose （FPG） （ r = 0. 375, P 〈 0. 050） were positively correlated. Multiariabie Logistic regression analysis showed that UACR （ OR = 1. 587, P 〈 0. 050） was a recent independent risk factors of poor prognosis in patients with AIS. Conclusion UACR the illness severity and recent prognosis of patients With AIS is closely related to high levels of UACR may be recent independent risk
出处
《中国基层医药》
CAS
2016年第3期333-337,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
卒中
脑缺血
白蛋白尿
危险因素
预后
Stroke
Brain ischemia
Albuminuria
Risk factor
Prognosis
