摘要
人类的肠道菌群种类超过1000种,总数多达100万亿,肠微生态失调与肠内外多种疾病密切相关。粪菌移植是将健康人的粪菌移植到患者胃肠道内,帮助纠正患者失衡的肠道菌群和重建具有正常功能的肠道微生态。目前,粪菌移植对难辨梭状芽孢杆菌感染具有良好疗效已获广泛认同;其对于与菌群失调相关的其他肠道内外疾病的治疗作用也成为研究热点,但是众多研究的结论并不一致,存在较多争议。另外,有关粪菌移植技术标准化、安全性评估以及发挥治疗作用的机制等方面尚未形成共识,仍待更多深入研究。本文就肠道菌群与肠内外疾病的联系、粪菌移植实施方案及其治疗潜力等内容结合国内外最新进展进行综述,为粪菌移植能更好服务于临床提供参考。
Human gastrointestinal（GI） tract contains at least 1014 bacteria,which can be categorized into more than 1 000 different species.Dysbiosis of intestinal flora is closely associated with many GI disorders and other extraintestinal conditions.There has been increasing interest in the application of fecal microbiota transplantation（FMT）-the administration of fecal solution from a healthy donor into the intestinal tract of a patient-in order to change gut microbial dysbiosis and help to build microbiota with normal function.To date,FMT has been shown to be safe and effective with resolution of clostridium difficile infection.There has been a growing numbers of FMT-based intervention studies to investigate whether this technique can benefit other GI and extraintestinal disorders associated with gut microbial dysbiosis.Despite this increased attention,outcomes from different studies are quite inconsistent.Moreover,further studies are required to standardize procedures,assess the safety and understand the mechanisms of this therapy.In this review,we explore and analyze the relationships between the role of gut microbiota and human health,detailed procedures and therapeutic potentials of FMT and provide reference for its further clinical application.
出处
《中华消化病与影像杂志（电子版）》
2016年第1期28-35,共8页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
基金
国家自然科学基金(NSFC81225003)
关键词
肠道菌群
粪菌移植
实施方法
治疗潜力
Gut microbiota
Fecal microbiota transplantation
Procedures
Therapeutic potential
