摘要
目的:探讨阿莫西林联合甲强龙治疗老年支气管肺炎患者的临床效果及其可能的作用机制。方法:选取我院呼吸科收治的老年支气管肺炎患者84例,根据治疗方案不同分为常规组及试验组。比较两组患者治疗前后临床体征、Ig A、Ig M、Ig G、CD4+及CD8+T淋巴细胞、NK细胞及血清LDH3、LDH4、HBDH水平的变化情况。结果:治疗后,试验组咳喘、高热、肺内干湿罗音的恢复时间明显短于常规组,Ig A、Ig M、Ig G、LDH、HBDH、NK细胞及CD8+T淋巴细胞水平明显低于常规组,CD4+T淋巴细胞水平明显高于常规组,差异均具有统计学意义(P<0.05)。结论:阿莫西林联合甲强龙可有效快速改善老年支气管肺炎患者的临床症状,这可能与其降低Ig A、Ig M、Ig G、LDH、HBDHNK细胞及CD8+T淋巴细胞水平及提高CD4+T淋巴细胞水平有关。
Objective： To investigate the clinical effect and mechanism of amoxicillin combined with methylprednisolone on the treatment of bronchial pneumonia for elderly patients. Methods： 84 elderly patients with bronchial pneumonia who were treated in our hospital were selected and randomly divided into the control group and the experimental group by different treatment. The clinical signs, IgM, IgG, IgA, CD4^＋ and CD8^＋, NK cells and LDH3, LDH4 and HBDH levels were compared before and after treatment. Results： After treatment, the recovery time of cough and asthma, hyperpyrexia, rhonchi and moist rales were significantly shorter than those of the control group（P〈0.05）, the IgA, IgM, IgG, CD8^＋, NK cell levels and serum LDH, HBDH levels were lower（P〈0.05）, while the CD4^＋ T lymphocyte levels were significantly higher （P〈0.05）. Conclusion： Amoxicillin combined with methylprednisolone could significantly improve the clinical symptoms of elderly patient with bronchial pneumonia, which might be related to the decrease of IgA, IgG, IgM, LDH, HBDH levels and NK, CD8^＋T lymphocyte levels and enhancement of CD4^＋ T lymphocyte levels.
出处
《现代生物医学进展》
CAS
2015年第35期6904-6907,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金地区项目(81060008)
