摘要
目的探讨早产儿血清巨噬细胞移动抑制因子(MIF)和磷脂转运蛋白(PLTP)表达及在支气管肺发育不良(BPD)中的临床意义。方法选择2013年1至2014年10月我院新生儿重症监护病房收治的体重<2 000 g、诊断为新生儿呼吸窘迫综合征和(或)予以机械通气的早产儿,超过28天仍氧依赖者为BPD组,日龄不足28天就已停用氧气者为对照组。入选患儿分别在生后第1、7、14、21、28天留取血清,用酶联免疫吸附(ELISA)法测定MIF和PLTP含量。结果 BPD组共纳入15例,对照组共纳入25例。BPD组各时间点血清MIF水平(ng/ml)均高于对照组[1天(19.5±1.4)比(8.0±7.0),7天(19.0±1.9)比(10.3±8.5),14天(18.6±2.3)比(11.2±8.3),21天(18.8±1.9)比(11.3±7.4),28天(19.1±1.4)比(11.6±7.8),P<0.05],14、21、28天时血清PLTP水平(ng/ml)低于对照组[14天(13.4±1.5)比(17.1±2.2),21天(14.0±1.6)比(21.7±3.0),28天(14.9±1.5)比(24.4±1.7),P<0.05]。结论 BPD患儿血清中MIF高度表达,PLTP表达水平相对较低,提示二者水平调控可能与BPD发生有关。
Objective To study the serum macrophage migration inhibitory factor （MIF） and phospholipid transfer protein （PLTP）levels in preterrn infants with bronchopulmonary dysplasia （BPD）. Methods Total of 75 preterm infants admitted to NICU from January 2013 to October 2014 with body weight （BW） less than 1 500 g, diagnosis of RDS and （or） mechanical ventilation were assigned into BPD group （ oxygen dependent for more than 28 days） and control group （ oxygen successfully withdrawal within 28 days）. Exclusion criteria including inadequate timing （discharge within 28 days, discontinued treatment or death）, unqualified specimen, congenital heart disease and other factors, such as inherited metabolic disease. Blood sample were taken at 1 d, 7 d, 14 d, 21 d and 28 d after birth, and MIF and PLTP were determined using ELISA method. Results There were 15 cases were in the BPD group, and 25 in the control group. MIF in BPD group were higher than the control group at each time point, PLTP in BPD group were lower than the control group at 14 d, 21 d and 28 d. Conclusions MIF is highly expressed in BPD infants, while PLTP expression is relatively low, suggesting that the regulation of the two factors may be occurred in BPD.
出处
《中国新生儿科杂志》
CAS
2016年第1期40-42,共3页
Chinese Journal of Neonatology
关键词
支气管肺发育不良
巨噬细胞移动抑制因子
磷脂转运蛋白
婴儿
早产
Bronchopulmonary dysplasia
Macrophage migration inhibitory factor
Phospholipid transfer protein
Infant,premature
