摘要
目的分析中期生长因子(MK)在甲状腺良性和恶性结节患者血清中的水平,探讨MK对诊断甲状腺结节良恶性的临床意义。方法收集因"甲状腺结节"入院行切除术171例患者的血清,收集健康体检各项指标均正常的22例正常人血清,采用酶联免疫吸附试验(ELISA)检测MK的浓度。结果良性结节患者122例,MK的浓度为(1.54±0.57)ng/ml,恶性结节患者49例,MK的浓度为(3.46±1.44)ng/ml,正常对照组MK的浓度为(1.44±0.45)ng/ml。甲状腺恶性结节组血清中MK浓度明显高于良性结节组,两组间有显著性差异(P<0.05),而甲状腺良性结节组与正常对照组的血清MK浓度接近,组间差异无统计学意义(P>0.05);采用ROC曲线分析,以2.25ng/ml为阈值,对诊断甲状腺恶性结节有较高的诊断效能。结论甲状腺恶性结节患者血清中MK浓度明显高于良性结节患者和正常人群,血清MK对甲状腺良恶性结节的诊断具有一定的临床意义。
Objective To investigate the clinical significance of MK in the diagnosis of benign and malignant thyroid nodules in patients with benign and malignant thyroid nodules by analyzing the level of MK in patients with benign and malignant thyroid nodules. Methods Collect 171 patients who admission line resection because of thyroid nodule,collect 22 normal human serum whose indicators of healthy check-up are normal,use ELISA to detect the level of MK The serum was collected from 171 patients with ＂thyroid nodules＂admitted to hospital,and the serum from 22 normal human was also collected. The concentration of MK was detected by enzyme linked immunosorbent assay（ ELISA）. Results The level of MK in 122 patients with benign nodules was（ 1. 54 ± 0. 57） ng /ml. The level of MK in 49 patients with malignant nodules was（ 3. 46 ± 1. 44） ng /ml. The level of MK in normal control group was（ 1. 44 ± 0. 45） ng / ml. The concentration of MK in the serum of malignant thyroid nodules group was significantly higher than that in benign nodules group,and there was a significant difference between the two groups. There was no significant difference in serum MK concentration between the benign thyroid nodules group and the controlgroup. ROC curve analysis had higher efficiency when it was used to diagnose the malignant thyroid nodules with 2. 25 ng / ml as the threshold value. Conclusion The serum levels of MK in patients with malignant thyroid nodules were significantly higher than those of benign nodules and normal people,and the serum MK level has a certain clinical significance in the diagnosis of benign and malignant thyroid nodules.
出处
《湖北科技学院学报（医学版）》
2016年第1期7-10,共4页
Journal of Hubei University of Science and Technology(Medical Sciences)
