摘要
目的探讨奥美沙坦酯及苯磺酸氨氯地平对男性高血压患者性功能的影响。方法选取2012年1月—2014年6月在江阴市中医院门诊就诊的男性高血压患者160例（高血压分级为1-2级）,采用随机数字表法将患者分为奥美沙坦酯组和苯磺酸氨氯地平组,各80例。奥美沙坦酯组给予奥美沙坦酯20 mg/d口服,苯磺酸氨氯地平组给予苯磺酸氨氯地平5 mg/d口服,疗程均为24周。观察两组治疗前后性功能和血清睾酮、雌二醇水平的变化。性功能评定按照勃起功能国际问卷-5（IIEF-5）进行问卷调查,主要通过勃起功能、性交满意度、达到高潮能力、性欲、总体满意度分值评价男性性功能。结果奥美沙坦酯组和苯磺酸氨氯地平组各有5例患者因血压持续不达标而退出。两组患者治疗后收缩压、舒张压比较,差异均无统计学意义（t=0.802、0.811,P〉0.05）。治疗前两组勃起功能、性交满意度、达到高潮能力、性欲、总体满意度分值比较,差异均无统计学意义（P〉0.05）;治疗后两组性交满意度、达到高潮能力、总体满意度分值比较,差异均无统计学意义（P〉0.05）;奥美沙坦酯组勃起功能、性欲评分均高于苯磺酸氨氯地平组,差异有统计学意义（P〉0.05）;治疗后两组雌二醇水平比较,差异无统计学意义（P〉0.05）;奥美沙坦酯组睾酮水平高于苯磺酸氨氯地平组,差异有统计学意义（P〈0.05）。奥美沙坦酯组治疗后睾酮水平高于治疗前,差异有统计学意义（P〈0.05）。结论奥美沙坦酯能提高男性高血压患者睾酮水平,改善性功能。
Objective To investigate the influence of olmesartan and amlodipine besylate on the sexual function of male hypertensive patients. Methods We enrolled 160 male hypertension patients（ the grades of hypertension was 1- 2 level）who received treatment in the Jiangyin Hospital of Traditional Chinese Medicine from January 2012 to June 2014. Using random number table method,we divided the patients into olmesartan group and amlodipine besylate group, with 80 patients in each group. Olmesartan group was administrated with olmesartan by 20 mg / d,and amlodipine besylate group was administrated with amlodipine besylate by 5 mg / d,with a course of treatment of 24 weeks. Changes in sexual function,testosterone and estradiol of the two groups before and after treatment were observed. Questionnaire survey was conducted on the sexual function according to international index of erectile function（ IIEF-5）, in which male sexual function was evaluated mainly by erectile function,satisfaction degree with sexual intercourse,ability of reaching orgasm,sexual desire and overall satisfaction degree. Results Each of the two groups had 5 patients who were excluded for the continual failure of blood pressure in reaching standard. The two groups were not significantly different in systolic pressure and dialostic pressure（ t = 0. 802,0. 811; P〉 0. 05）. Before treatment,the two groups were not significantly different in the scores of erectile function,the satisfaction degree with sexual intercourse,ability of reaching orgasm,sexual desire and overall satisfaction degree（ P〉 0. 05 for all）; after treatment,the two groups were not significantly different in the scores of satisfaction degree with sexual intercourse, the ability of reaching orgasm and the overall satisfaction degree（ P〉 0. 05 for all）,and the olmesartan group was higher than the amlodipine besylate group in the scores of erectile function and sexual desire（ P〈 0. 05）; the scores of erectile function and sexual desire of the olmesartan group after
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第6期648-651,共4页
Chinese General Practice
