摘要
血管钙化常见于高血压、糖尿病血管病变、动脉粥样硬化、慢性肾病、衰老等传统的老年病或慢性病,此外还可见于小儿,如新生儿期血管钙化、肺动脉高压、尿毒症性小动脉钙化等,均可危及生命。最近研究发现,血管钙化是一种多因素介导、可逆的、主动的调节过程,涉及多种细胞因子及信号通路,血管钙化的本质是血管平滑肌细胞向成骨细胞样表型转化,导致血管壁增厚、管腔狭窄、血管硬化重塑,因此血管钙化及其平滑肌细胞表型转化相关的信号转导调节机制成为这一领域的重大研究课题。
Vascular calcification is common in hypertension, atherosclerosis, diabetes, chronic kidney disease, aging, etc. Not only found in these elderly or chronic diseases, but also in children, such as neonatal vascular calcification, pulmonary hypertension, uremic small artery calcification, can endanger life. Recent studies have found that vascular calcification is a multi factor, reversible and active regulation process. It involves many kinds of cytokines and signaling pathways. The essence of vascular calcification is vascular smooth muscle cells to differentiate into osteoblast like phenotype. resulting in vascular wall thickening, lumen stenosis and vascular remodeling. Therefore, it is important to study the mechanism of vascular calcification and the modulation of the signal transduction pathway related to the phenotype of smooth muscle cells.
出处
《中国医药导报》
CAS
2016年第6期30-33,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81370972)
关键词
血管钙化
血管平滑肌细胞
表型转化
信号通路
Vascular calcification
Vascular smooth muscle cells
Cell phenotype transformation
Signaling pathway
