期刊文献+

幽门螺杆菌感染与根除治疗对功能性消化不良影响的研究

Evaluation of Helicobacter pylori eradication in patients with functional dyspepsia
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摘要 目的观察FD病人H.pylori感染及根除治疗对症状评分及胃肠道嗜酸粒细胞的影响.方法:选择2011年3月至2012年8月符合Rome Ⅲ标准的FD患者215例.基线时分别进行腹部症状问卷调查、胃镜检查及粘膜活检、病理组织学检查、H.pylori检测.H.pylori感染者行四联根除治疗.第2周和第6周分别行腹部症状问卷调查,部分病人第6周末复查胃镜及病理学检查.计数资料比较采用χ2检验,两样本均数比较用t 检验,嗜酸粒细胞集簇率比较采用χ2检验.结果: Warthin-Starry 染色和14C呼气试验双阳性90例,双阴性77例.H.pylori阳性组病人H.pylori根除率为69.0% (58/84).第6周末胃镜检查及病理活检患者H.pylori根除组36例、H.pylori未根除19例;基线时H.pylori阳性组与H.pylori阴性组临床症状评分差异无显著性,H.pylori根除组与H.pylori未根除组在基线、第2周及第6周三个时间点临床症状评分差异无显著性.两组以第2周症状评分与基线时和第6周比较症状评分均有明显改善;基线时H.pylori阳性组胃体及胃窦嗜酸粒细胞计数经胃镜检查显示较H.pylori阴性组比较呈明显增多,经检查显示在十二指肠球部及降部,H.pylori阳性组较H.pylori阴性组其嗜酸粒细胞计数未见显著增多.于第6周时胃镜检查显示H.pylori根除组在胃体和胃窦的嗜酸粒细胞计数与较H.pylori未根除组相比均有明显下降,十二指肠球部和降部两组间的嗜酸粒细胞计数差异无显著性;基线时H.pylori阳性组胃体、胃窦粘膜嗜酸粒细胞集簇现象发生率要显著高于H.pylori阴性组,两组病例间十二指肠球部或降部嗜酸粒细胞集簇现象发生率比较差异无显著性.另于第6周末复查胃镜及病理活检发现,H.pylori根除组与H.pylori未根除组两组比较,胃十二指肠4个部位嗜酸粒细胞集簇现象的发生率差异无显著性.另H.pylori根除组及H.pylori未根除组其胃十二指肠嗜酸粒细胞集簇现象在治疗� Objective To observe the effect of H.pylori infection and eradication therapy on symptom score and gastrointestinal eosinophils in patients with FD. Methods: 215 patients with FD from March 2011 to August 2012 were selected for Rome. At baseline, abdominal symptoms questionnaire, gastroscopy and mucosal biopsy, histopathological examination, H.pylori test were performed. For the quadruple eradication therapy of H.pylori infection. Second weeks and sixth weeks, respectively, the abdominal symptoms questionnaire survey, part of the patients sixth weeks to review the gastroscopy and pathological examination. Count data were compared using the 2 test, two samples were compared by t test, eosinophil cluster was compared by 2 test. Results: Warthin-Starry staining and 14C breath test were double positive in 90 cases and double negative in 77 cases. The eradication rate of H.pylori was 69% (58/84) in H.pylori positive group. 36 patients with gastroscopy and biopsy in the weekend were detected in sixth patients with H.pylori eradication, 19 patients with H.pylori, and the clinical symptoms of H.pylori positive group and H.pylori negative group were not significantly different from baseline, H.pylori eradication group and H.pylori group at baseline, second weeks and 6 Wednesday. Two groups to the 2 weeks of symptom scores and baseline and 6 weeks compared symptom scores were significantly improved; baseline H.pylori-positive group of gastric body and antrum eosinophil eosinophil cell count by gastroscopy showed that compared with H.Pylori-negative group was significantly increased. The examination revealed in the duodenal bulb and descending part, H.pylori positive group than in H.Pylori-negative group the eosinophil eosinophil cell count showed no significant increase. In the 6 weeks gastroscopy showed that H.pylori eradication group in the gastric body and antrum of the eosinophil eosinophil cell count and a H.pylori not eradication group were significantly decreased compared, duodenal bulb and descending part o
出处 《世界中医药》 CAS 2015年第A02期1563-1566,共4页 World Chinese Medicine
关键词 消化不良 嗜酸粒细胞 幽门螺杆菌 药物疗法 dyspepsia eosinophils Helicobacter pylori drug therapy
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参考文献20

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