摘要
维生素D与心血管健康和疾病的关系越来越引起人们的重视,研究发现维生素D缺乏与心血管疾病的危险因素,如高血压、内皮功能异常、胰岛素抵抗、代谢综合征和糖尿病等相关,从而增加冠状动脉性疾病的危险性。维生素D与分布于心血管细胞上的维生素D受体结合,调节与心血管疾病过程相关的基因的表达。维生素D低水平状态通过激活促炎症瀑布导致内皮功能异常和动脉壁的硬度增加而增加心血管疾病的危险性。
The relationship of vitamin D and cardiovascular health and diseases attracts more and more attention in recent years.Study indicates that vitamin D deficiency is associated with risk factors of cardiovascular diseases,such as hypertension,endothelial dysfunction,insulin resistance,metabolic syndrome and diabetes mellitus and increase the risk of the development of cardiovascular diseases.Vitamin D combines with vitamin D receptor that is distributed on cardiovascular cells and regulates expressions of many genes associated with cardiovascular diseases process.Status of low vitamin D level activated pro-inflammatory cascade resulted in endothelial dysfunction and increased stiffness of vessel wall which increases risk of cardiovascular diseases.
出处
《中华临床医师杂志（电子版）》
CAS
2016年第2期279-283,共5页
Chinese Journal of Clinicians(Electronic Edition)
关键词
维生素D
心血管疾病
危险因素
进展
Vitamin D
Cardiovascular disease
Risk factors
Progress
