摘要
目的分析糖化血红蛋白（Hb A1c）在糖耐量正常（NGT）人群中的分布特点及相关因素。方法选择北京市首钢四个社区糖尿病普查人群的资料,所有参加者进行人体学测量、75 g葡萄糖耐量试验（OGTT）,同时检测Hb A1c、空腹血糖（FPG）、OGTT后2 h血糖值（2 h PG）及血生化。将9 711名符合入选标准的NGT人群的结果纳入分析,比较Hb A1c在不同性别及年龄组间（青年组、中年组、老年组及老老年组）的差异;根据Hb A1c水平分为≤5.6%、5.7%~6.4%和≥6.5%三组,比较三组的临床特点;采用Logistic回归方法分析与Hb A1c相关的因素。结果 （1）Hb A1c在NGT人群呈正态分布,平均（5.69±0.44）%,95%CI为4.83%~6.55%;男性与女性之间Hb A1c的水平有差异（P〈0.05）,尤其在老年组（60~79岁）差异显著（P〈0.01）。（2）Hb A1c随着年龄的增加逐渐升高,Hb A1c、FPG及2 h PG在青年组（16~44岁）与中年组（45~59岁）间均有统计学差异（P〈0.01）;Hb A1c、FPG在青年组、中年组都与老年组（60~79岁）和老老年组（≥80岁）间有统计学差异（P〈0.01）,而2 h PG与老老年组无统计学差异;老年组和老老年组无统计学差异。（3）Hb A1c≤5.6%与Hb A1c 5.7%~6.4%和≥6.5%组之间在年龄、体质量指数（BMI）、腰臀比（WHR）、收缩压（SBP）、血胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）水平、FPG和2 h PG均有统计学差异（P〈0.01或P〈0.05）;而Hb A1c 5.7%~6.4%与≥6.5%组之间比较差异均无统计学意义。（4）Logistic回归分析显示Hb A1c与性别、年龄、BMI、WHR、SBP、TC、FPG呈正相关,与DBP、HDL-C呈负相关。结论 NGT人群的Hb A1c随年龄的增长而升高,并与FPG呈正相关;处于高危Hb A1c范围的非糖尿病人群应加强对FPG、2 h PG和心血管危险因素的监测。
Objective To analyze the result of glycated hemoglobin（HbAlc） measurement and related factors in normal glucose tolerance（NGT） population.Methods A 75 g glucose tolerance test（OGTT） was administered in all participants from diabetes（DM） screening population of Shougang four community.HbAlc,fasting plasma glucose（FPG）,2 hour plasma glucose（2 h PG） after OGTT and blood biochemical test were conducted.Anthropometric measurements were performed to all the subjects.A total of 9 711 individuals with normal FPG and 2 h PG were included for data analysis.All the subjects were divided into three groups by levels of HbAlc,and the clinical characteristics of the three groups were compared.Logistic regression was used to analyze the correlation of HbAlc to related factors.Results HbAlc was normally distributed in NGT populations.The range of HbAlc was 4.9%-6.5%,（5.69±0.44）%.There was difference in HbAlc between men and women（P〈0.05）.Especially,there was significant difference（P〈0.01） in the older group（60 to 79 years old）.HbAlc increased with age.There was significant differences among the young group（16 to 44 years old）,middle-aged group（45-59 years）,the elderly groups（60 to 79 years） and very elderly group（≥ 80 years） in HbAlc,FPG and 2 h PG（P〈0.01）,whereas there was no significant difference between the elderly groups and the very elderly group.There were statistically significant between HbAlc ≤ 5.6%group and HbAlc 5.7%-6.4%group,HbAlc ≥ 6.5%group in body mass index（BMI）,waist-hip ratio（WHR）,systolic blood pressure（SBP）,serum cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol（LDL-C） levels,FPG and 2 h PG（P〈0.01 or P〈0.05）,whereas there was no significant difference between HbAlc 5.7%-6.4%group and ≥ the 6.5%group.Logistic regression analysis showed that HbAlc was positively correlated with gender,age,BMI,WHR,SBP,TC,FPG and was negatively correlated with DBP,HDL-C.Conclusion HbAlc is positively corr
出处
《中华临床医师杂志（电子版）》
CAS
2016年第2期183-187,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
首都卫生发展专项(2011-4026-03)
