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自体富血小板凝胶用于糖尿病足溃疡的治疗效果 被引量:27

Effect of autologous platelet-rich gel on the treatment of diabetic foot ulcers
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摘要 目的初步评价自体富血小板凝胶(autologous platelet-rich gel,APG)在糖尿病足溃疡修复中的有效性。方法纳入60例糖尿病足溃疡患者(Wagner分级2级~3级),随机分为APG治疗组和重组牛碱性成纤维细胞生长因子凝胶对照组(传统对照组)。观察8周,从样本整体溃疡、表浅溃疡、窦道溃疡、Wagner 2级、Wagner 3级共5个层次,比较两组的创面治愈率、创面愈合时间。结果 APG治疗组与传统对照组患者从样本整体溃疡、表浅溃疡、窦道溃疡、Wagner 2级和Wagner 3级的5个层次比较,两组间的治愈率在样本整体溃疡(93.33%vs.63.33%,P=0.005)、窦道溃疡(84.62%vs.36.36%,P=0.033)、Wagner 3级(81.82%vs.30%,P=0.030)差异有统计学意义,在表浅溃疡(100%vs.78.95%,P=0.106)和Wagner 2级(100%vs.80%,P=0.106)差异无统计学意义;两组各层次的溃疡整体愈合中位数时间为31dvs.41.5d,23dvs.32d,32dvs.56d,25dvs.32d,38dvs.56d,差异均有统计学意义(P〈0.05)。结论 APG能够有效提高糖尿病足溃疡的治愈率,并缩短愈合时间。 Objective To evaluate the effectiveness of autologous platelct-rich gel (APG) in the repair of diabetic foot ulcers. Methods This study was a single-center, prospective, randomized controlled trial. A total of 60 patients with diabetic foot ulcers (Wagner grade 2 - 3) wcrc randomly divided into autologous APG group (treatment group) and recombinant bovine basic fibroblast growth factor gel group (control group). After 8 weeks, we compared wound healing rate and wound healing time at five levels (overall ulcer, superficial ulcer, sinus ulcer, Wagner 2 and Wagner 3) in the two groups. Results In APG treatment group and control group, the healing rate of overall sample ulcer (93.33% vs. 63.33%, P 0.005), sinus ulcer (84.62% vs. 36.36%, P= 0.033), Wagncr 3 (81.82% vs. 30%, P=0.030) differed significantly, but did not significantly differ in superficial ulcer (100% vs. 78.95%, P =0.106) or Wagner 2 (100% vs. 80%, P=0.106). Ulcer healing time was 31 d vs. 41.5d, 23d vs. 32 d, 32 d vs. 56 d, 25 d vs. 32 d, 38 d vs. 56 d, with significant difference between the two groups (P〈0.05). Conclusion Autologous platelet-rich gel can effectively increase the curative rate of diabetic foot and shorten healing time.
出处 《西安交通大学学报(医学版)》 CAS CSCD 北大核心 2016年第2期264-267,共4页 Journal of Xi’an Jiaotong University(Medical Sciences)
基金 新疆维吾尔自治区自然科学基金资助项目(No.2014211C129)~~
关键词 自体富血小板凝胶 糖尿病足 溃疡 治疗 成纤维细胞生长因子 autologous platelet-rich gel diabetic foot ulcer treatment fibroblast growth factor
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