摘要
目的研究尤瑞克林联合奥扎格雷钠治疗急性脑梗死的疗效及对神经功能缺损和血液流变学的影响。方法选取2014年1月至2015年3月武汉市东西湖区人民医院收治的72例急性脑梗死患者,根据随机数字表法分为观察组(36例)和对照组(36例)。对照组采取奥扎格雷钠治疗,静脉滴注80 mg,每日2次;观察组患者在此基础上联合使用尤瑞克林,在剂量为100 m L的0.9%Na Cl注射液中将0.15肽核酸(PNA)尤瑞克林相混合,并进行静脉滴注,在0.5 h内完成滴注。观察两组患者治疗前与治疗后半个月神经功能缺损程度、梗死体积、血液流变学的变化,比较两组患者治疗后的临床疗效。结果治疗后,观察组患者的神经功能缺损评分及梗死体积显著低于对照组[(10.2±2.9)分比(15.0±3.0)分,(4.52±0.24)cm3比(5.52±0.36)cm3],差异有统计学意义(P<0.01)。治疗后,观察组患者总的有效率显著高于对照组[91.67%(33/36)比63.89%(23/36)],差异有统计学意义(P<0.05)。治疗后,观察组患者的纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度指标均低于对照组[(2.46±0.32)g/L比(4.13±1.01)g/L,(1.32±0.21)m Pa·s比(1.67±0.35)m Pa·s,(7.25±0.98)m Pa·s比(10.03±1.05)m Pa·s,(3.21±0.53)m Pa·s比(4.67±0.85)m Pa·s],差异有统计学意义(P<0.05)。结论急性脑梗死患者采取尤瑞克林并辅助奥扎格雷钠进行治疗,患者的神经功能缺损与血液流变学可得到明显改善,临床疗效较好,安全性高。
Objective To study the effect of kallikrein joint ozagrel treatment of acute cerebral infarction and its effect on neurological impairment and hemorbeology. Methods From Jan. 2014 to Mar. 2015,72 cases of acute cerebral infarction from Wuhan Dongxihu District People＇s Hospital were included in the study, according to a random number table all patients were divided into observation group （36 cases） and control group（ 36 cases）. The control group received ozagrel treatment（ 80 mg iv, 2 times per day）, the observation group was given kallikrein on the basis of ozagrel（0. 15 PNA dissolved in 100 mL 0. 9% NaCl for intravenous influsion within 0. 5 h）. Before treatment and two weeks after treatment,neurological deficit,infarct volume, hemorheology changes of the two groups were observed. After treatment, the clinical efficacy of the two groups were compared. Results After treatment, the neurological deficit scores and infarct volume the observation group was significantly lower than the control group[ （ 10. 2±2.9） scores vs （ 15.0±3.0） scores, （4. 52±0. 24） cm^3 vs （5.52 ±0. 36）cm^3 ] ,the difference was statistically significant （P 〈0. 01 ）. After treatment, the total efficacy of the observation group was higher than the control group [91.67% （33/36） vs 63.89% （23/36） ], the differences were statistically significant （ P 〈 0. 05 ）. After treatment, the fibrinogen plasma viscosity, low shear whole blood viscosity, high shear whole blood viscosity indicators of the observation group were better than the control group [ （2. 46 ± 0. 32） g/L vs （4. 13 ± 1.01 ） g/L, （ 1.32 ＋ 0. 21 ） mPa ·s vs （1.67 ±0.35） mPa·s,（7.25 ± 0.98） mPa·s vs （10.03 ±1.05） mPa·s,（3.21 ± 0.53） mPa·s vs （4.67 ±0.85） mPa · s] ,the differences were statistically significant （P 〈0.01）. Conclusion Kallikrein assisted with ozagrel treatment of acute cerebral infarction, can significantly improve the patient＇s neurological deficit and hemorheolog
出处
《医学综述》
2016年第5期1000-1002,1005,共4页
Medical Recapitulate
