摘要
目的：对左氧氟沙星不良反应分析及临床合理用药效果进行研究分析.方法：选取60例左氧氟沙星不良反应患者的临床资料进行研究分析,并对其用药状况进行研究.结果：左氧氟沙星不良反应主要出现在年龄≥60岁、女性、静脉给药方法、每日用药剂量≥400mg患者群体中,其不良反应发生率显著高于年龄为18-59岁、男性、局部给药、口服给药和每日用药剂量〈400mg患者的,差异有显著性（P 〈0.05）;63.33%涉及皮肤及附件、10.00%涉及消化系统、8.33%涉及神经系统、8.33%涉及心血管系统、10.00%为过敏性休克.结论：左氧氟沙星不良反应会累及患者全身各个组织和器官,用该药治疗时应考虑患者年龄、性别、药剂量和给药方式等,尽可能降低不良反应发生率,做到合理安全用药.
Objective: To analyze the adverse reaction of levofloxacin and clinical rational drug use. Methods:Select 60 cases of patients with adverse reaction to levofloxacin,analyze their clinical data and their drug use status.Results: Adverse reaction to levofloxacin mainly occurred in patients who were no less than 60-year-old,female,received intravenous administration and daily dosage no less than 400 mg. The adverse reaction incidence of patients above was significantly higher than patients who were between the age 18 and 59,male,received local and oral delivery,and daily dosage less than 400mg( P < 0. 05). Among the adverse reaction,63. 33% referred to skin,10. 00%to digestive system,8. 33% to nervous system,8. 33% to cardiovascular system and 10. 00% to allergic shock. Conclusion: Adverse reaction to levofloxacin covers every tissues and organs of the body,the age,gender,drug use method and dosage of patients should be considered when giving drug administration to reduce adverse reaction incidence.
出处
《数理医药学杂志》
2016年第3期402-403,共2页
Journal of Mathematical Medicine
关键词
左氧氟沙星
不良反应
临床合理用药
Levofloxacin
adverse reaction
clinical rational drug use
