摘要
目的探讨雌激素相关受体β在胃癌组织中的表达及其临床意义。方法选取109例胃癌手术标本和42例癌旁正常组织,采用免疫组化SP法检测ERRβ表达,分析ERRβ与胃癌临床病理特征及患者预后的关系。结果 ERRβ在胃癌组织中阳性表达率为68.8%,高于癌旁正常组织的16.7%(P<0.05)。ERRβ表达与肿瘤浸润深度(P=0.016)、淋巴结转移(P=0.028)、分化程度(P=0.005)关系密切,而与年龄、性别、远处转移和肿瘤大小等无关。109例患者的中位生存时间(OS)为21.0个月,ERRβ阳性表达者中位OS为11.0个月,低于阴性表达者的34.0个月(P<0.001)。Cox多因素分析显示,ERRβ表达是影响胃癌预后的独立因素。结论 ERRβ在胃癌组织中表达增高,且与患者预后有关,可作为判断胃癌患者预后的有效分子标志物。
Objective To explore the expression of the ERR[3 in human gastric carcinoma tissues and its clinical significance. Methods The expression of ERR[3 in 109 samples of gastric carcinoma and 42 samples of normal gastric tissues were de- tected by immunohistoehemistry. The relationship among ERRβ expression and the clinical data and overall survival（OS） was analyzed. Results The positive ERR[3 expression rate of gastric carcinoma was 68.8%, which was significantly higher than that （ 16. 7% ） of normal gastric mucosa tissues （P〈0. 05）. The expression of ERRβ had correlation with lymph node metastasis, infiltration depth and the differentiation degree in gastric carcinoma （P= 0. 016, P= 0. 028, P= 0. 005）. However, it had no correlation with gender, age and the size of tumor. The median OS of 109 patients was 21.0 months. The median OS of patients with positive ERRβ expression was 11.0 months, which was significantly shorter than 34. 0 months of ERRβ negative expression（P〈0. 001 ）. Conclusion The expression levels of ERRβ was increased and correlated with poor prognosis, which may be a powerful molecular marker to predict the progrosis of gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2016年第2期152-155,共4页
Chinese Clinical Oncology
基金
国家自然青年科学基金项目(81201949)
