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非结核分枝杆菌肺病患者血清细胞因子测定临床意义分析 被引量:1

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摘要 目的分析非结核分枝杆菌(non-tuberculosis mycobacteria,NTM)肺病患者中血清细胞因子含量及其可能的临床意义。方法选择35例NTM肺病患者和29例陈旧性肺结核患者,通过酶联免疫分析法,检测其血清中白介素2受体(IL-2 R)、白介素6(IL-6)、白介素8(IL-8)、白介素10(IL-10)、肿瘤坏死因子α(TNF-α)和降钙素原(procalcitonin,PCT)的含量,分析其与肺部空洞的关系。结果 35例NTM肺病患者血清TNF-α含量为(14.6±2.6)pg/m L,显著高于对照组的(9.2±1.8)pg/m L,差异有统计学意义(P=0.026)。NTM肺病患者血清IL-2 R含量为(1026.2±545.3)U/m L,IL-6为(10.6±6.4)pg/m L,IL-8为(12.7±3.9)pg/m L,IL-10为(5.3±1.8)pg/m L,PCT为(0.07±0.01),与对照组比较差异均无统计学意义。NTM肺病患者中7例空洞患者与28例无空洞患者血清IL-2 R、IL-6、IL-8、IL-10、TNF-α、PCT含量差异均无统计学意义。结论 TNF-α在NTM肺病的感染和形成过程中起着非常重要的作用,是NTM肺病感染的重要指标。
作者 李红
机构地区 鞍山市千山医院
出处 《当代医学》 2016年第6期29-30,共2页 Contemporary Medicine
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