摘要
目的采用99Tcm—MIBI门控心肌灌注显像分析杜兴型肌营养不良（DMD）早期心肌受累特点，评价糖皮质激素治疗效果，帮助临床DMD相关心肌病的早期诊断，及早干预治疗、提高生存率。方法收集神经肌肉标本库中确诊DMD患者77例，99Tcm-MIBI门控心肌灌注显像定量分析左室功能及心肌灌注缺损部位、程度和范围：动态观察糖皮质激素治疗DMD心肌损害效果。结果DMD心肌病累及左室各壁、各节段，以左室下壁、心尖最易受累；心肌受累程度与年龄呈正相关（rS=0．534）；间歇静脉糖皮质激素冲击联合连续口服糖皮质激素治疗可显著改善DMD患者心脏损害。结论99Tcm-MIBI门控心肌灌注显像评估DMD心肌损害准确度、灵敏度72．阳性率高．适于早期诊断DMD亚临床期心肌损窖：动态评估糖度盾激素疗效．
Objective We aimed to identify early changes of myocardial involvement in DMD patients and to evaluate the efficacy of treatments by applying 99Tcm-MIBI gated myocardial perfusion imaging （G-MPI）.Methods Total 77 DMD patients were con- ducted by applying 99Tcm-MIBI G-MPI.Results 99Tcm-MIBI G-MPI analysis revealed myocardial defect in every segment of the left ventrieular wall, especially in inferior walls and the apexes in DMD patients. The degree of cardiac involvement was posi- tively correlated with the age in DMD patients （rS=0.534）.Conclusions 99Tcm-MIBI G-MPI is a sensitive and safe approach for early evaluation of cardiomyopathy,subsequent dynamic observation of its progress,and prognosis of glucocorticoid treatment in DMD patients.
出处
《中国药业》
CAS
2015年第B12期152-154,共3页
China Pharmaceuticals
基金
河北省医学科学研究重点课题计划项目,项目编号：20150274.
