摘要
目的探讨小剂量米非司酮治疗子宫肌瘤的临床疗效。方法回顾性分析整群选取的该院收治的2013年6月—2015年4月对69例子宫肌瘤患者,采用米非司酮12.5 mg/d,连续3个月治疗的临床观察数据,并与治疗前作自身对照。结果所有患者在治疗3个月后子宫体积以及肿瘤体积明显缩小,与治疗前相比差异具有统计学意义(P<0.05),治疗半年后患者的子宫体积以及肿瘤体积与治疗前相比差异具有统计学意义(P<0.01),治疗3个月以及半年后患者的雌激素、卵泡刺激素以及黄体生成素水平与治疗前相比明显降低,差异具有统计学意义(P<0.05)。结论本研究结果表明临床上对于子宫肌瘤患者采用小剂量米非司酮治疗的效果显著,能有效控制肿瘤组织的生长,降低机体的激素水平,并且临床上未发生严重的不良反应,是保守治疗的理想选择,因此值得临床推广。
Objective To study the clinical effect of low-dose mifepristone in treatment of uterine fibroids. Methods Clinical observation data of three consecutive months of treatment of 69 cases with uterine fibroids using mifepristone 12.5mg/d from June 2013 to April 2015 was retrospectively analyzed and compared with pretherapy. Results After 3 months of treatment, Uterine volume and tumor volume of all patients were significantly decreased compared with pretherapy and the difference was significant （P〈0.05）, after six months of treatment, Uterine volume and tumor volume were significantly different from pretherapy ,and the difference was very significant （P〈0.01）. after 3 months and six months of treatment, Estrogen, follicle stimulating hormone and progesterone levels of patients were significantly decreased compared with pretherapy, which was statistically significant （P〈0.05）. Conclusion The research results show that the clinical effect of low-dose mifepristone in treatment of patients with uterine fibroids is significant, which can effectively control the growth of tumor tissue and reduce the body＇s hormone levels and there was no serious adverse reactions clinically. It is an ideal choice for conservative treat-ment, so it is worthy of clinical promotion.
出处
《中外医疗》
2015年第34期144-146,共3页
China & Foreign Medical Treatment
关键词
子宫肌瘤
小剂量米非司酮
临床治疗效果
回顾性分析
Uterine fibroids
Low-dose mifepristone
Clinical therapeutic effect
Retrospectively analyzed
