摘要
目的探讨环磷酰胺联合泼尼松治疗特发性间质性肺炎的临床效果。方法将100例特发性间质性肺炎患者按照随机数字表法均分为对照组和观察组。对照组患者仅应用泼尼松治疗,观察组患者用泼尼松联合环磷酰胺治疗,比较两组治疗后的临床疗效。结果观察组患临床总有效率为96.00%,明显高于对照组的70.00%(P<0.05),治疗后肺功能各项指标均优于对照组(P<0.05)。经过治疗后,观察组患者美国胸科学会呼吸困难修正评分量表(MMRC)评分为(0.92±0.28)分,明显低于对照组的(3.69±0.81)分(P<0.05)。结论环磷酰胺联合泼尼松治疗特发性间质性肺炎具有良好的临床效果,并无明显药品不良反应,患者呼吸困难等临床症状及体征得到明显改善,生活质量有所提高。
Objective To investigate the clinical efficacy of cyclophosphamide combined with prednisone on patients with idiopathic in- terstitial pneumonia. Methods 100 cases of idiopathic interstitial pneumonia were randomly divided into the control group and the ob- servation group, 50 cases in each group. The control group only used prednisone, the observation group was given cyclophosphamide com- bined with prednisone. The clinical efficacy of the two groups were compared after treatment. Results The total effective rate of the ob- servation group was 96. 00%, whcih was significantly higher than 70. 00% of the control group（P 〈 0. 05）; after treatment, the lung function indexes of the observation group were significantly better than those of the control group（ P 〈 0.05）; the MMRC score of the observation group was （0. 92 ± 0.28） points, which was significantly lower than （3.69 ± 0. 81） points of the control group （ P 〈 0.05）. Conclusion Cyclophosphamide combined with prednisone in the treatment of patients with idiopathic interstitial pneumonia has good clinical efficacy, with no obvious adverse drug reaction. The clinical symptoms and signs of dyspnea are improved obviously, as well as the patients＇ quality of life.
出处
《中国药业》
CAS
2016年第3期32-35,共4页
China Pharmaceuticals
关键词
环磷酰胺
泼尼松
特发性间质性肺炎
临床疗效
cyclophosphamide
prednisone
idiopathic interstitial pneumonia
clinical efficacy
