摘要
目的:系统评价中西医结合治疗小儿轮状病毒性肠炎(Rotavirus enteritis)的有效性以及安全性。方法:计算机检索The Cochrane Library,Embase,中国期刊全文数据库(CNKI),Pubmed,中国生物医学文献数据库(CBM),中国科技期刊全文数据库(VIP)和万方数据库等中英文数据库,检索时间限定为建库至2015年6月27日,检索所有中西医结合治疗小儿轮状病毒性肠炎的随机对照试验(randomized controlled trials,RCTs),并追索纳入研究的参考文献。由两位评价者独立对符合纳入标准的研究进行严格质量评价和资料提取后,应用Rev Man 5.3软件进行Meta分析。结果:最终纳入28项研究,共4 227例患儿。Meta分析结果显示:与常规西医治疗方案相比,中西医结合治疗小儿轮状病毒性肠炎能显著提高临床疗效[OR=5.10,95%CI(4.07,6.39),P<0.000 01],有效缩短退热时间[MD=-0.30,95%CI(-0.46,-0.13),P=0.000 4],有效缩短止泻时间[MD=-1.42,95%CI(-2.18,-0.66),P=0.000 3],提高轮状病毒转阴率[OR=5.59,95%CI(3.55,8.78),P<0.000 01],其差异均具有统计学意义。发表性偏倚分析结果提示纳入研究可能存在潜在发表偏倚。结论:相比于常规西医治疗方案,中西医结合治疗具有提高小儿轮状病毒性肠炎临床疗效,缩短退热时间、止泻时间,提高轮状病毒转阴率的优势。鉴于本系统评价纳入研究的方法学和报告质量均不高,故此项研究仍需要严格的、大样本、多中心的随机对照试验加以验证。
Objective： To systematically evalate the safety and efficacy of intergrated traditional Chinese and western medicine in treating infantile rotavirus enteritis. Method： We searched The Cochrane Library, Embase, CNKI, Pubmed, CBM, VIP and Wanfang Data from database inception to June 27, 2015. The Randomized Controlled Trials （RCTs） of intergrated traditional Chinese and western medicine in treating infantile rotavirus enteritis in any language were included, and recover into research references. Two researchers extracted data and assessed the literature quality separatedly, and made a Meta analysis using RevMan 5.3 software. Result： 28 RCTs involving 4 227 patients entered the inclusion criteria. The Meta analysis results showed that compared with western medicine, intergrated traditional Chinese and western medicine can significantly improve the clinical tatal effecctive rate [ OR = 5.10, 95% CI （4.07, 6.39）, P 〈 0.000 01 ], effectively shorten the defervescencetime [MD = -0.30, 95% CI （ -0.46, -0.13）, P =0.000 4], and shorten the time of diarrhoea [MD = - 1.42, 95% CI （ -2.18, -0.66）, P =0.000 3], increase the rate of turn rotavirus [OR=5.59, 95% CI （3.55, 8.78）, P 〈 0.000 01], the difference between two groups is statistically significant. ＇Funnel Plot＇ bias analysis results indicate that there may be a potential publication bias. Conclusion： The current results indicates that intergrated traditional Chinese and western medicine in treating infantile rotavirus enteritis can effectively improve the clinical effective rate, effectively shorten the defervescence time, and shorten the time of diarrhoea, increase the rate of turn rotavirus. However, the quality of methodology and report of small sample of RCTs are low, and the efficacy and safety of intergrated traditional Chinese and western medicine in treating infantile rotavirus enteritis still need more strict, large sample, randomized, double- blind trials to make the conclusion more reliable.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第4期182-188,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金青年项目(61301294)
国家级大学生创新创业训练项目(201510572007)
关键词
中西医结合疗法
轮状病毒性肠炎
随机对照试验
META分析
intergrated traditional Chinese-western medicine
rotavirus enteritis
randomized controlledtrial
Meta-analysis
