摘要
髓源性抑制细胞（myeloid—derivedsuppressorcells，MDSCs）作为一群具有免疫抑制功能的异质细胞，不仅可以抑制由T细胞介导的抗肿瘤免疫，而且还可直接刺激血管生成，肿瘤生长和转移。而非可控性炎症（nonresolvinginflammation，NRI）又是肿瘤发生发展的重要驱动因素，两者都存在于肿瘤微环境中，是近年的研究热点，进展较快，但相互之间的关系，特别是分子传导通路异同之处，尚未完全阐明，该文结合文献和本课题组的工作，综合介绍两者之间的关系，及相关分子调控网络图，探讨关键调控节点和针对性治疗策略。
Myeloid-derived suppressor cells （MDSCs） are a heterogeneous group of immunosuppres- sire cells derived from bone marrow stem cells. MDSCs can not only strongly inhibit the anti-tumor immune reac- tions mediated by T cells, but also directly accelerate angiogenesis, tumor progression and metastasis. Nonre- solving inflammation （NRI） , a major driving factor in the occurrence and development of tumor, and MDSCs are present in tumor microenvironment and become hot topics in recent years. However, the relationships be- tween MDSCs and NRI, especially in the relevant molecular regulatory networks, have not been fully elucidated. The relationships between MDSCs and NRI, the molecular regulatory networks, the key regulatory points and the strategies for targeted treatment are reviewed in this paper based on the current literatures and the work achieved by our research team.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2016年第1期72-78,共7页
Chinese Journal of Microbiology and Immunology
关键词
髓源性抑制细胞
非可控性炎症
分子调控网络
靶向治疗
Myeloid-derived suppressor cells
Nonresolving inflammation
Molecular regulatory net-work
Targeted therapy
