摘要
目的探讨不同年龄晚期非小细胞肺癌(NSCLC)患者的临床特点、治疗方法及预后因素。方法回顾性分析128例晚期NSCLC患者的临床资料,根据年龄分为老年组(86例)和青年组(42例)。分析比较两组患者的临床特点、治疗方法及治疗后的生存状况。结果老年组患者的年龄为(72.10±0.21)岁,青年组患者的年龄为(36.34±0.13)岁。青年组中女性吸烟患者占42.9%,高于老年组女性患者(19.8%),差异有统计学意义(P<0.05)。老年组患者罹患心血管疾病、呼吸系统疾病、消化系统疾病和糖尿病者分别为55.8%、43.0%、46.5%和39.5%,高于青年组(分别为11.9%、19.0%、21.4%和9.5%),差异有统计学意义(P<0.05)。老年组男性患鳞癌比例(26.7%)高于青年组(9.5%),青年组女性腺癌患者比例(33.0%)高于老年组(12.8%),差异有统计学意义(P<0.05)。老年组患者治疗方式以放化疗方式为主(分别为75.6%和16.7%),而青年组患者以手术切除方式为主(分别为83.0%和19.8%),差异有统计学意义(P<0.05)。老年组患者1、3和5年生存率分别为64.3%、47.5%和29.9%,青年组分别为74.3%、53.5%和36.9%,差异均无统计学意义(P>0.05)。结论青年组非小细胞肺癌患者女性多见,肺腺癌所占比例较大,接受手术治疗的比例大。而老年组患者则肺鳞癌所占比例大,伴有其他系统疾病多见。青年和老年非小细胞肺癌患者的预后差异不大。
Objective To investigate whether the clinical characteristics, treatment modalities and prognosis of elderly patients with advanced non-small cell lungcancer differed from those of young patients. Methods A retrospective study was performed in 128 patients with advanced non-small cell lung cancer who were divided into two groups, the elderly group and the young group. The clinical characteristics, treat- ment modalities and prognosis were analyzed and compared. Results The mean age in the elderly group and young group was （72. 10 ±0. 21 ） and （36. 34 ±0. 13） year. The smoking female in the young group were more than those in the elderly group （42. 9% vs 19. 8% ）, with significant difference （P 〈0. 05）. The patients with cardiovascular disease, respiratory disease, gastrointestinal disease, diabetes in the elder- ly group were more than those in the young group （55.8% vs 11.9%, 43.0% vs 19. 0%, 46. 5% vs 21.4%, 39. 5% vs 9. 5% ）, with significant difference （P 〈0.05）. Men suffering from squamous cell car- cinoma in the elderly group were more than those in the young group （26. 7% vs 9.5% ）, the number of fe- male patients with adenocarcinoma of the young group was more than in the older group （ 33.0% vs 12. 8% ）, and the difference was statistically significant （ P 〈 0. 05）. The major treatment modality in theelderly group was the radiotherapy and chemotherapy （75.6% vs 16. 7% ） ; The major treatment modality in the young group was the surgery （83.0% vs 19. 8% ） ; The difference was statistically significant between the two groups （ P 〈 0. 05 ）. The survival rate of 1 -, 3-, 5-yr in the elderly group were 64. 3 % , 47.5 % and 29. 9% ; The survival rate of 1-, 3-, 5-yr in the young group were 74. 3% , 53.5% and 36. 9% ; The differ- ence was not statistically significant between the two groups （ P 〈 0. 05 ）. Conclusions In young patients with non-small cell lung cancer, female and adenocarcinoma make up the majority of the number, and a lot of patients
出处
《中国肿瘤临床与康复》
2016年第2期149-152,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
