摘要
目的探讨醋酸甲羟基孕酮联合抗生素治疗子宫内膜炎的临床效果。方法将2013年6月-2014年12月我院收治的80例子宫内膜炎患者随机分为对照组（40例）和观察组（40例）,观察组采用醋酸甲羟基孕酮片联合抗生素治疗,对照组采用抗生素治疗,比较两组的临床疗效、月经情况和治疗前后细胞因子水平变化情况。结果观察组的总有效率为92.5%（37/40）,明显高于对照组的70.0%（28/40）,差异有统计学意义（P〈0.05）;观察组阴道不规则出血率（7.5%）明显低于对照组（37.5%）,月经恢复正常率（92.5%）明显高于对照组（62.5%）,差异有统计学意义（P〈0.05）;观察组治疗后的白细胞介素-4、基质金属蛋白酶-9水平明显低于对照组,白细胞介素-10高于对照组,差异有统计学意义（P〈0.05）。结论醋酸甲羟基孕酮联合抗生素相对于单独使用抗生素更有利于提高对子宫内膜炎的治疗效果、改善月经情况和减轻炎症反应,值得在临床上推广。
Objective To explore the clinical effect of medroxyprogesterone acetate combined with antibiotics treating endometritis. Methods 80 patients with endometritis received by our hospital from June 2013 to December 2014 were randomly divided into control group（n=40） and observation group（n=40）.Patients in observation group were treated by medroxyprogesterone acetate combined with antibiotics.Patients in control group were treated by.Clinical effect,menstrual condition and the change of cytokine level before and after treatment between two groups was compared respectively.Results The total effective rate [92.5%（37/40）] in observation group was obviously higher than that [70.0%（28/40）] of control group,and the difference was statistical significance（P〈0.05）.Irregular vaginal bleeding rate in observation group（7.5%） was obviously lower than that（37.5%） in control group;while the menstrual recover to normal rate（92.5%） was obviously higher than that（62.5%） in control group,and the difference was statistical significance（P〈0.05）.After treatment,the level of IL-4 and MMP-9 in observation group was obviously lower than that of control group,while IL-10 was higher than that of control group,the difference was statistical significance（P〈0.05）. Conclusion Compared with using antibiotics simply,medroxyprogesterone acetate combined with antibiotics is more helpful to improve the therapy effect for endometritis,improve menstrual condition and alleviate inflammatory reaction.It is worth to popularize in clinic.
出处
《中国当代医药》
2016年第5期83-85,共3页
China Modern Medicine
关键词
醋酸甲羟基孕酮
抗生素
子宫内膜炎
联合治疗
Medroxyprogesterone acetate
Antibiotics
Endometritis
Combined treatment
