摘要
目的研究血清MMP-26在IPF患者中的水平,探讨其在IPF患者发病过程中的临床价值。方法收集10例IPF患者血清为实验组、10例健康成人血清为对照组。采用酶联免疫吸附法(ELISA)测定血清MMP-26含量,并与HRCT、动脉血气分析、呼吸困难程度及肺功能进行相关分析。结果健康成人血清MMP-26浓度为(7.33±1.65)μg/L,IPF患者血清MMP-26浓度为(5.72±0.55)μg/L,两者差异有统计学意义(P<0.05)。IPF患者血清MMP-26浓度与HRCT严重程度及呼吸困难严重程度呈负相关,与PaO_2呈正相关,而与P(A-a)O_2、PaCO_2、HCO_3^-浓度水平以及肺功能无明显相关性(P>0.05)。结论 MMP-26可能参与了IPF的发病过程;MMP-26可作为IPF严重程度及预后的一项参考指标。
Objective To study serum MMP-26 levels in patients with idiopathic pulmonary fibrosis（ IPF） and explore its clinical significance. Methods Collect 10 patients with IPF as the experimental group,and 10 healthy adults as control group. Using enzyme-linked immunosorbent assay（ ELISA） to determine the level of MMP-26 in serum,and analyze the results of high-resolution CT,arterial blood gas analysis,the degree of dyspnea and pulmonary function. Results The MMP-26 concentration（ 5. 72 ± 0. 55 μg / l） from patients with IPF was lower than that of normal control group（ 7. 33 ± 1. 65 μg / l）,and the difference was statistically significant（ P〈0. 05）. The serum concentration of MMP-26 of the patients with IPF was negatively correlated to the HRCT severity and the severity of dyspnea,while positively correlated to the PaO_2,and the correlations between serum concentration of MMP-26 of the patients with IPF and P（ A-a）O_2,PaCO_2,HCO_3^-concentration levels and pulmonary function were not significant. Conclusion MMP-26 may be involved in the pathogenesis of IPF.MMP-26 could be used as a reference index of IPF severity and prognosis.
出处
《遵义医学院学报》
2016年第1期47-50,共4页
Journal of Zunyi Medical University
基金
遵义汇川区科技局资助项目(NO:209.001.122.09)
