摘要
目的观察不同剂量丙种球蛋白治疗重型小儿口足病的临床疗效。方法遵义市妇幼保健院儿科2013年6月至2015年6月收治2期、3期手足口病患儿96例,随机分为小剂量组和大剂量组各48例。两组患儿在常规治疗和对症治疗的基础上静脉注射不同剂量丙种球蛋白,小剂量组注射剂量为1g/kg,大剂量组注射剂量为2g/kg,比较两组患儿临床症状消失时间、临床治愈时间、住院时间、并发症以及经济效益。结果两组患儿临床症状消失时间、临床治愈时间、住院时间比较差异无统计学意义(P>0.05);大剂量组患儿的并发症发生率为16.7%(8/48),高于对照组2.1%(1/48),差异有统计学意义(P<0.05);另外小剂量组治疗费用更低。结论不同剂量的丙种球蛋白治疗重型手足口病疗效均显著且相近,而剂量为1g/kg的丙种球蛋白治疗费用更低、患儿并发症发生率低,值得推广和运用。
Objective To observe the clinical effect of gamma globulin at different doses in the treatment of children with severe HFMD. Methods A total of 96 children with HFMD at stage Ⅱ and Ⅲ were treated in Zunyi Maternity and Child Health Care Hospital from June 2013 to June 2015, and they were divided randomly into two groups：the small-dose group and the large-dose group,with 48 cases in each group. The two groups were given conventional and symptomatic treatment, and in addition to that, they were injected intravenously different doses of gamma globulin, with 1 g/kg for the small-dose group and 2 g/kg for the large-dose group. Compare the time for clinical symptoms to disappear, the time of being clinically cured, the hospital stay,the complications and the hospitalization expenses between the two groups. Results There was no statistical difference in the time for clinical symptoms to disappear,the time of being clinically cured and the hospital stay（P〉0.05）. The complication incidence was 16. 7 % （8/48） in the large-dose group, higher than the small-dose one, which was 2.1% （ 1/48）, and the difference was statistical significance （ P〈 0.05 ）. The expense in the small-dose group was lower. Conclusion The effect of gamma globulin at different doses is similar and significant in the treatment of severe HFMD. When the dose is 1 g/kg,the treatment expense is lower and the complication incidence is lower,so it is worthy of being clinically applied.
出处
《中国中西医结合儿科学》
2016年第1期79-81,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
