摘要
COPD是一种具有不完全可逆性气流阻塞特征的慢性炎性疾病，常伴有心血管疾病增加、静脉血栓栓塞风险和系统性炎症反应等并发症，是全球发病和死亡的主要原因之一。FEV1是在疾病严重程度和进展方面使用最广泛的的指标，鉴于其与症状和疾病进展其他方面存在较弱的相关性，探索能充分体现COPD特征的标志物更是备受关注。纤维蛋白原是急性时相反应蛋白，也是凝血系统中重要的凝血因子，纤维蛋白原与其降解产物Aα-Val^360以及纤维蛋白降解产物D-二聚体可以作为监测疾病进展和急性发作的潜力标志物。在此主要从静脉血栓栓塞以及炎症反应等方面对相关生物学标志物进行阐述，以进一步理解其在疾病发生、发展中的作用，为疾病的监测和治疗预防提供新的思路。
Chronic obstructive pulmonary disease （COPD） is a chronic inflammatory disease that is characterised by airflow obstruction that is not fully reversible, often associated with an increase in cardiovascular disease, risk of venous thromboembolism and systemic inflammatory response complication, which is a major global cause of morbidity and mortality. Forced expiratory volume in one second （FEV1） is the most widely used parameter in the severity and progression of disease. The markers reflecting sufficiently the characteristics of COPD are attracted more attention considering that FEV1 correlates poorly with both symptoms and other measures of disease progression. Fibrinogen is acute phase reaction protein and important clotting factor in blood coagulation system, fibrinogen with its degradation product Aα-Val^360 and fibrin degradation product D-dimer may used as the potential markers to monitor the disease progression and exacerbation. Here we will mainly explain related biological markers in terms of venous thromboembolism and inflammatory response, further understanding of its role in disease development to provide a new thought for the monitoring and treatment of disease prognosis.
出处
《国际呼吸杂志》
2016年第2期138-141,共4页
International Journal of Respiration
基金
国家自然科学基金面上项目（81170035）
湖北省自然科学基金项目（2010CDB08903）
