摘要
[目的]观察苦参素对丙肝失代偿期肝硬化患者的抗纤维化和免疫调节作用,以及分析了其相关的临床疗效。[方法]收集2013年3月~2015年2月我院收治的丙肝失代偿期肝硬化患者76例,随机分为常规治疗对照组和苦参素治疗组,每组38例。比较2组治疗前后HA、LN、PCⅢ、CⅣ、IL-17、IL-10、HCV-RNA病毒载量和Child-Pugh评分的变化。[结果]治疗前2组HA、LN、PCⅢ和CⅣ表达差异无统计学意义（P〉0.05）,治疗后2组均出现显著减低（P〈0.05和P〈0.01）。但治疗组的减低作用显著高于对照组（P〈0.01）。治疗前2组IL-17和IL-10表达差异无统计学意义（P〉0.05）,治疗后2组IL-17和IL-10表达均出现显著改变（P〈0.05和P〈0.01）,但治疗组对IL-17和IL-10表达的改善作用优于对照组（P〈0.05）。治疗前2组Child-Pugh评分和HCV-RNA病毒载量差异无统计学意义（P〉0.05）,治疗后2组均出现显著减低（P〈0.05和P〈0.01）。但治疗组的减低作用显著高于对照组（P〈0.01）。[结论]苦参素可以调节丙肝失代偿期肝硬化患者体内Th17/Treg免疫失衡,发挥抗纤维化作用,显著减低Child-Pugh评分和HCV-RNA病毒载量,临床疗效显著,值得临床推广使用。
[Objective]To observe the anti-fibrosis and immune regulation effect of matrine on hepatitis C virus（HCV）infected patients with decompensated cirrhosis and explore its clinical efficacy.[Methods]A total of 76 HCV infected patients with decompensated cirrhosis was enrolled in this study and devided into control（n=38）and matrine treatment group（n=38）.The changes of HA,PC,LN,C,HCV-RNA,IL-17,IL-10,HCV-viral load and Child-Pugh score in the two groups was compared before and after the treatment.[Results]Before the treatment,HA,LN,PC Ⅲ,C Ⅳ,HCV-RNA,IL-17,IL-10,HCV-viral load and Child-Pugh score showed no significant difference between the control and the treatment group（P〈0.05）.After the treatment,HA,LN,PC Ⅲ,C Ⅳ,HCV-RNA,IL-17,IL-10,HCV-viral load and Child-Pugh score were obviously decreased in the two groups（P〈0.05 or P〈0.01）.However,the above indexes of the treatment group significantly lower than those in the control group（P〈0.01）.[Conclusion]Matrine could regulate Th17/Treg imbalance,resulting in anti-fibrosis effect,and reduce the Child-Pugh score and HCVRNA virus load in HCV infected patients with decompensated cirrhosis with obvoious clinical efficacy,worthy of clinical application.
出处
《中国中西医结合消化杂志》
CAS
2016年第1期41-43,47,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
