摘要
目的研究低钠血症与SCLC患者预后的关系。方法回顾分析2010---2012年于浙江省肿瘤医院收治的489例SCLC患者病史资料。489例患者中低钠血症110例。低钠血症发生率比较采用疋。检验，采用Kaplan-Meier法计算生存率并Logrank检验，Cox模型分析低钠血症对预后影响程度。结果初次治疗前、2程化疗后、放疗后、末次治疗结束后低钠血症发生率分别为17．9％、13．3％、12．5％、18．9％，上述阶段伴低钠血症患者与血钠正常者3年生存率分别为10．1％：21．1％（P=0．000）、14．7％：20．5％（P=0．022）、12．1％：28．3％（P=0．000）、7．0％：21．8％（P=0．000），上述阶段低钠血症患者死亡危险分别是血钠正常患者的1．297倍（95％CI=1．160～1．449，P=0．000）、1．366倍（95％CI=1．023～1．825，P=0．035）、1．770倍（95％CI=1．168～2．682，P=0．007）、1．507倍（95％CI=1．167—1．944，P=0．002）。结论低钠血症是影响SCLC患者生存的因素。
Objective To investigate the association between hyponatremia and the prognosis of patients with small cell lung cancer （SCLC）. Methods The clinical data of 489 patients with SCLC who were treated in Zhejiang Cancer Hospital from January 1, 2010 to December 31, 2012 were retrospectively analyzed. 110 patients have hyponatremia in all patients. Hyponatremia incidence was compared with X2 test. Survival rates were calculated by the Kaplan-Meier method and compared by the log-rank test. The Cox proportional hazards model was applied to analyze the prognostic factors including hyponatremia . Results Before initial treatment, after 2 cycles of chemotherapy, after radiotherapy, and after the end of the last treatment, the incidence of hyponatremia was 17.9%, 13.3%, 12. 5%, and 18. 9%, respectively; the 3- years survival rate were 10. 1% vs. 21.1%（P=0.000） ,14.7% vs. 20. 5%（P=0. 022） ,12. 1% vs. 28.3% （P=0. 000） ,7. 0% vs. 21.8%（P=0. 000） with hyponatremia than normal blood sodium, respectively. The Cox regression analysis showed that the relative risk of death in patients with hyponatremia was elevated I. 297 times （95% CI= 1. 160-1. 449, P= 0. 000）, 1. 366 times （95% CI= 1. 023-1. 825, P= 0. 035）, 1. 770 times （95% CI= 1. 168-2. 682,P= 0. 007）, and 1. 507 times （95% CI= 1. 167-1. 944,P= 0. 002） in before initial treatment, after 2 cycles of chemotherapy, after radiotherapy, and after the end of the last treatment. Conclusion Hyponatremia is an independent prognostic factor for patients with SCLC.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2016年第2期126-130,共5页
Chinese Journal of Radiation Oncology
基金
国家自然科学基金项目( 81402540)Fund program:National Natural Science Foundation of China
关键词
低钠血症
癌
小细胞肺/化学疗法
癌
小细胞肺/放射疗法
预后
Hyponatremia
Carcinoma, small cell lung/chemotherapy
Carcinoma, small cell lung/radiotherapy
Prognosis
