摘要
目的系统性分析复方甘草酸苷治疗皮炎湿疹的疗效及安全性。方法计算机检索中国期刊全文数据库、Cochrane图书馆、万方数字化期刊全文数据库及Medline等,收集所有关于比较联合复方甘草酸苷片与单独常规治疗方法（糖皮质激素和/或口服抗组胺药）治疗皮炎湿疹临床疗效的随机对照试验,检索时间范围为各数据库建库至2015年7月。对收集的文献进行筛选、质量评价和发表偏倚的情况分析,并评价复方甘草酸苷治疗皮炎湿疹的疗效与安全性。结果初检出相关文献102篇,去除重复文献48篇,通过阅读文题与摘要初步纳入35篇,阅读全文后最终纳入20篇,均为近6年发表的中文文献,共计1 745例患者,其中试验组患者共878例,对照组患者867例。20个研究均报告了复方甘草酸苷片治疗皮炎湿疹临床比较的计数结果,以总有效率=（痊愈率＋显效率＋好转率）为疗效指标进行meta分析。其同质性检验表明20个研究之间具有同质性（P=0.52,I2=0%）,故采用固定效应模型进行分析。Meta分析结果显示：合并统计量OR值及95%CI为（OR=3.21,95%CI：2.25-4.57）,显著性检验Z=6.44（P=0.000 01）,表明试验组与对照组治疗的总有效率的差异具有统计学意义,常规治疗（糖皮质激素和/或口服抗组胺药）联合复方甘草酸苷片治疗皮炎湿疹的临床疗效优于单独的常规治疗。联合复方甘草酸苷片的安全性较好,不良反应发生率较常规治疗低。结论经研究结果显示,采用复方甘草酸苷联合治疗神经性皮炎和慢性湿疹疗效显著且安全。但因本次研究及评价系统具有一定局限性,因此还需扩大研究样本深入研究,以得出更为准确的结论。
Objective Systematic analysis of the efficacy and safety of compound glycyrrhizin in the treatment of dermatitis and eczema. Methods We searched the Chinese Journal Full-text database, Cochrane Library, Articles Digital Periodicals Full Text Database and Medline, etc, and collected literature of compound glycyrrhizin in the treatment of dermatitis and eczema from the establishment of the database to July 2015. Then analyzed the literature on screening, quality evaluation and publication bias, and evaluated the efficacy and safety of compound glycyrrhizin in the treatment of dermatitis and eczema. Results Early detection of relevant literature was 102, then removed duplicate documents 48, initially 35 articles were included by reading the text and abstracts, and 20 articles were included by reading the whole text finally, which were Chinese literature published in the past six years, including a total of 1 745 cases of patients, 878 cases of patients in experimental group, 867 cases of patients in control group. 20 studies （see list of references） of clinical comparison results were reported in compound glycyrrhizin tablets in the treatment of dermatitis and eczema, overall response rate （cure rate ＋ markedly effective ＋ improvement rate） conducted a recta-analysis of the efficacy of indicators. Its homogeneity test showed that among 20 studies having homogeneity （P = 0.52, 12 = 0%）, so the use of fixed-effects model analysis. Meta-analysis showed： Consolidated Statistics OR value and 95% CI （OR = 3.21,95% CI： 2.25 ~ 4.57 ）, significant test Z = 6.44 （P = 0.000 O1 ）, shows that efficiency of the experimental group and the control group were statistically significantly different.. The efficiency of conventional treatment （ corticosteroids and / or oral antihistamines） combined with compound glycyrrhizin tablets in the treatment of dermatitis and eczema is superior better than that of conventional treatment alone with lower adverse reactions. Conclusion The study shows that the effici
出处
《中国处方药》
2016年第2期1-4,共4页
Journal of China Prescription Drug
