摘要
目的了解河北省任丘市城乡老年居民颈动脉斑块特征与新发心脑血管事件的关系。方法经随机整群抽样法，以河北省任丘市年龄60—70岁的常住居民为筛查对象，进行面对面健康问卷调查、颈部血管超声检查，共筛查4413例，其中男性1876例，女性2537例，利用超声检测受检者颈动脉斑块、狭窄的发生情况。根据颈动脉斑块的回声、有无狭窄将颈动脉斑块分为有无斑块、有无狭窄、单发与多发、均质与不均质斑块，分析颈动脉斑块特征与新发心脑血管事件的关系。结果4413例中，颈动脉无斑块1975例（44．8％），颈动脉斑块形成2438例（55．2％），颈动脉狭窄235例（5.3％）。单发斑块、多发斑块、均质斑块、不均质斑块的患病情况分别为1024例（23．2％）、1414例（32．0％）、1106例（25．1％）、1333例（30．2％），其中单发斑块新发心脑血管事件83例（P=0．168），多发斑块新发心脑血管事件161例（P〈0．001），均质斑块新发心脑血管事件98例（P=0．032），不均质斑块新发心脑血管事件146例（P〈0．001），狭窄新发心脑血管事件42例（P〈0．001）。以新发心脑血管事件为因变量，单因素分析显示，颈动脉斑块（x2=14．969，P〈0．001）、多发斑块（x2=22．509，P〈0．001）、颈动脉狭窄（x2=27．561，P〈0．001）、均质斑块（x2=4．606，P〈0.050）、不均质斑块（x2=18．301，P〈0.001）、高血压史（x2=33．709，P〈0．001）、高脂血症史（x2=11．262，P〈0．001）、糖尿病史（x2=5．525，P〈0．050）、冠心病史（x2=10，440，P〈0．001）、性别（x2=5.606，P〈0．050）、吸烟（x2=4．823，P〈0．050）、收缩压数值均与新发心脑血管事件有关。多因素分析显示，颈动脉不均质斑块（β=0．371，P〈0．050）、颈动脉狭窄（β=0．621，P〈0．050）、高血压史（β=0．517，P〈0．001）、吸烟（β=0�
Objective To investigate the potential relationship between the characteristics of atherosclerotie plaque of carotid artery and cardiovascular events in a senior cohort of Renqiu region, Hebei. Methods A random clll^t~!~ ~ampling method was used to identify study population amollg fi0 -70 years old residence in Renqiu region, Hebei. In the face of health questionnaire survey,neck vascular ultrasound examination, a total of 4 413 cases, inclu- ding 1 876 males and 2 537 females, the occurrence of carotid artery plaque and stenosis were detected by ultrasound. Carotid ultrasound was used to identify the characteristic of atherosderotic plaque of bilateral carotid arteries, which were categorized as with and without plaque, single and multiple plaque, homogenous .and heterogeneous plaque, and with and without stenosis. Cardiovascular events were defined as composite events of myocardial infarction, cardiovas- cular death, fatal or non - fatal stroke during the subsequent 2 years follow - up after initial evaluation, Multiple Logis- tic regression was performed to identify the association between the characteristics of bilateral carotid arteries and cardiovascular events. Results A total of 4 413 case enrolled in the study. With carotid ultrasound, 2 438 cases （55. 2% ） were found to be with atherosclerotic plaque formation and 235 （5.3%） were with carotid artery stenosis. The proportion of single, multiple, homogeneous and heterogeneous plaques were 1 024cases （ 23.2% ） , 1 114cases （32.0%） , l 106cases （ 25.1% ） and 1 333cases （ 30.2% ） , respectively. Among them, the single plaque and new cardiovascular and cerebrovascular events occured in 83 cases （P = 0.168）, the multiple plaques and new cardiovascular and cerebrovascular events occured in 161 cases （ P 〈 0. 001 ）, the homogeneous patch and new cerebral vascular events oceured in 98 cases （ P = 0. 032 ） , the non - homogeneous patch and new cerebral vascular events occured in 146 cases（P 〈 0.001 ）,the stenosis and cer
出处
《中国基层医药》
CAS
2016年第1期95-101,共7页
Chinese Journal of Primary Medicine and Pharmacy
