摘要
目的：了解医院近5年铜绿假单胞菌的临床分布特点及其对各种抗菌药物的耐药性,以指导临床用药。方法监测2010年1月~2014年12月医院临床1417株分离铜绿假单胞菌的耐药状况,用 Kirby-Bauer 纸片扩散法检测细菌耐药性,参照2010~2014年版美国临床实验室标准化协会（CLSI）标准判定药敏结果,并用 WHONET5.6软件统计分析。结果5年共分离铜绿假单胞菌1417株,占所有分离菌株的20.33%（1417/6970）,其中痰液中分离1123株,占79.3%,2013年铜绿假单胞菌对抗菌药物的耐药率较前三年明显上升,但在2012~2013年医院进行抗菌药物专项整治后,2014年铜绿假单胞菌对部分抗菌药物如氨曲南、头孢他啶、头孢哌酮/舒巴坦、头孢吡肟、亚胺培南、美罗培南、哌拉西林/他唑巴坦等耐药率均有明显下降。结论铜绿假单胞菌是医院感染的常见致病菌之一,易产生多重耐药性,了解其临床分布和耐药性的变迁,可以为临床治疗提供资料,更好的控制铜绿假单胞菌的感染。
Objective To understand clinical distribution characteristics and drug resistance of pseudomonas aeruginosa in recent 5 years, so as to guide clinical medication. Methods Drug resistance by 1417 strains of pseudomonas aeruginosa in January 2010~December 2014 was taken under monitoring. Kirby-Bauer disk diffusion method was applied to detect bacterial drug resistance, and the outcome was made in accordance with American clinical and laboratory standards institute （CLSI） standard in 2010~2014. Statistical analysis was made by WHONET5.6 software. Results There were totally 1417 strains of pseudomonas aeruginosa separated in the recent 5 years, accounting for 20.33% （1417/6970）. Among them, 1123 strains were separated from sputum, accounting for 79.3%. In 2013, drug resistance by pseudomonas aeruginosa for antibiotics was obviously higher than that in former three years. After implement of concentrative management for antibiotics in 2013~2013, drug resistance by pseudomonas aeruginosa was remarkably reduced for aztreonam, ceftazidime, cefoperazone/sulbactam, cefepime, imipenem, meropenem, piperacillin/tazobactam. Conclusion As one of the common pathogenic bacteria, pseudomonas aeruginosa is easily to show drug resistance. Understanding of changes in its clinical distribution and drug resistance can provide data to clinical treatment, and control infection by pseudomonas aeruginosa.
出处
《中国实用医药》
2016年第1期7-9,共3页
China Practical Medicine
关键词
铜绿假单胞菌
抗菌药物
耐药性
Pseudomonas aeruginosa
Antibacterial agents
Drug resistance
