摘要
目的检测特发性肺纤维化患者外周血中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-17(IL-17)的表达,探讨其与肺纤维化改变的关系。方法对49例特发性肺纤维化患者、47例健康人(正常组)以及45例普通肺炎(肺炎组)外周血中TNF-α、IL-6和IL-17表达水平进行检测。结果与正常组相比,肺炎组患者血清中IL-6、IL-17表达水平无差异,不具有统计学意义(P>0.05),肺炎组血清中TNF-α表达增高,差异有统计学意义(P<0.05);与正常组相比,肺纤维化组血清中IL-6、IL-17和TNF-α浓度呈明显升高趋势(P<0.01);与肺炎组相比,肺纤维化血清中组IL-6、IL-17和TNF-α浓度呈明显升高趋势(P<0.01)。结论 TNF-α、IL-6和IL-17表达水平与肺部纤维化改变密切相关,其表达水平对疾病诊断、治疗和预后的评估均有一定的实用价值。
Objective To detect the serum levels of IL-6, IL-17 and TNF-α in patients with idiopathic pulmonary fibrosis, and to study the relationship between the pulmonary fibrosis and the serum levels. Methods The serum levels of IL-6, IL-17 and TNF-α were detected in the following three groups, the idiopathic pulmonary fibrosis group （ n = 49 ）, the control group （ n = 47 ）, and the common pneumonia group （ n = 45 ）. Results Compared with the control group, the levels of IL-6 and IL-17 showed no statistical difference in the common pneumonia group （P 〉 0. 05）, but the level of TNF-α increased significantly in the common pneumonia group （P 〈 0. 05 ）. Compared with the control group, the serum levels of IL-6, IL-17, and TNF-α increased obviously in the idiopathic pulmonary fibrosis group （P 〈0. 01 ）. Compared with the pneumonia group, the serum levels of IL-6, IL-17, and TNF-α increased significantly in the idiopathic pulmonary fibrosis group （ P 〈 0. 01 ）. Conclusion The expression of TNF-α, IL-6 and IL-17 is closely related with the changes of pulmonary fibrosis, and it has certain clinical value on the assessment of diagnosis, treatment and prognosis.
出处
《临床肺科杂志》
2016年第3期531-532,540,共3页
Journal of Clinical Pulmonary Medicine
关键词
特发性肺纤维化
白细胞介素-6
白细胞介素-17
肿瘤坏死因子-Α
idiopathic pulmonary fibrosis （IPF）
interleukin-6 （ IL-6 ）
interleukin-17 （ IL-17 ）
tumor necrosis factor-α （TNF-α）
